Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations

G-quadruplexes (G4s) are secondary structures that can form in both DNA and RNA from guanine-rich sequences which are enriched in untranslated regions (UTRs). Here, Lee et al. find that putative G4-forming sequences are evolutionarily constrained, enriched for RNA-binding protein interactions and en...

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Autores principales:	David S. M. Lee, Louis R. Ghanem, Yoseph Barash
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a81acb8a15f44cb5b34ac2f1cb19717d
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spelling	oai:doaj.org-article:a81acb8a15f44cb5b34ac2f1cb19717d2021-12-02T16:56:33ZIntegrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations10.1038/s41467-020-14404-y2041-1723https://doaj.org/article/a81acb8a15f44cb5b34ac2f1cb19717d2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14404-yhttps://doaj.org/toc/2041-1723G-quadruplexes (G4s) are secondary structures that can form in both DNA and RNA from guanine-rich sequences which are enriched in untranslated regions (UTRs). Here, Lee et al. find that putative G4-forming sequences are evolutionarily constrained, enriched for RNA-binding protein interactions and enriched for disease genetic associations.David S. M. LeeLouis R. GhanemYoseph BarashNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David S. M. Lee Louis R. Ghanem Yoseph Barash Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations
description	G-quadruplexes (G4s) are secondary structures that can form in both DNA and RNA from guanine-rich sequences which are enriched in untranslated regions (UTRs). Here, Lee et al. find that putative G4-forming sequences are evolutionarily constrained, enriched for RNA-binding protein interactions and enriched for disease genetic associations.
format	article
author	David S. M. Lee Louis R. Ghanem Yoseph Barash
author_facet	David S. M. Lee Louis R. Ghanem Yoseph Barash
author_sort	David S. M. Lee
title	Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations
title_short	Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations
title_full	Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations
title_fullStr	Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations
title_full_unstemmed	Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations
title_sort	integrative analysis reveals rna g-quadruplexes in utrs are selectively constrained and enriched for functional associations
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a81acb8a15f44cb5b34ac2f1cb19717d
work_keys_str_mv	AT davidsmlee integrativeanalysisrevealsrnagquadruplexesinutrsareselectivelyconstrainedandenrichedforfunctionalassociations AT louisrghanem integrativeanalysisrevealsrnagquadruplexesinutrsareselectivelyconstrainedandenrichedforfunctionalassociations AT yosephbarash integrativeanalysisrevealsrnagquadruplexesinutrsareselectivelyconstrainedandenrichedforfunctionalassociations
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Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations

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