N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke

Causing more and more deaths, stroke has been a leading cause of death worldwide. However, success in clinical stroke trials has remained elusive. N-oleoylethanolamine (OEA) was an endogenous highly hydrophobic molecule with outstanding neuroprotective effect. In this article, hydrogen bonds were su...

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Autores principales:	Xiangrui Yang, Shichao Wu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	stroke n-oleoylethanolamine (oea) neuroprotective drug delivery dspe-peg Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a81f59bc04eb4fedbe68e5bf37b5aecc
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spelling	oai:doaj.org-article:a81f59bc04eb4fedbe68e5bf37b5aecc2021-12-01T14:40:58ZN-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke1071-75441521-046410.1080/10717544.2021.2008058https://doaj.org/article/a81f59bc04eb4fedbe68e5bf37b5aecc2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/10717544.2021.2008058https://doaj.org/toc/1071-7544https://doaj.org/toc/1521-0464Causing more and more deaths, stroke has been a leading cause of death worldwide. However, success in clinical stroke trials has remained elusive. N-oleoylethanolamine (OEA) was an endogenous highly hydrophobic molecule with outstanding neuroprotective effect. In this article, hydrogen bonds were successfully formed between OEA and soybean phosphatidylcholine (SPC). The synthetic OEA-SPC complex and DSPE-PEG were self-assembled into liposomes (OEA NPs), with OEA-SPC loaded in the core and PEG formed a hydrophilic shell. Hence, highly hydrophobic OEA was loaded into liposomes as amorphous state with a drug loading of 8.21 ± 0.18 wt%. With fairly uniform size and well-distributed character, the OEA NPs were systemically assessed as an intravenous formulation for stroke therapy. The results indicated that the administration of OEA NPs could significantly improve the survival rate and the Garcia score of the MCAO rats compared with free OEA. The TTC-stained brain slices declared that the cerebral infarct volume and the edema degree induced by MCAO could be decreased to an extremely low level via the administration of OEA NPs. The Morris water maze (MWM) test suggested that the spatial learning and memory of the MCAO rats could also be ameliorated by OEA NPs. The immunofluorescence assay stated that the apoptosis of the neurons and the inflammation within the brain were greatly inhibited. The results suggest that the OEA NPs have a great chance to develop OEA as a potential anti-stroke formulation for clinic application.Xiangrui YangShichao WuTaylor & Francis Grouparticlestroken-oleoylethanolamine (oea)neuroprotectivedrug deliverydspe-pegTherapeutics. PharmacologyRM1-950ENDrug Delivery, Vol 28, Iss 1, Pp 2525-2533 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke n-oleoylethanolamine (oea) neuroprotective drug delivery dspe-peg Therapeutics. Pharmacology RM1-950
spellingShingle	stroke n-oleoylethanolamine (oea) neuroprotective drug delivery dspe-peg Therapeutics. Pharmacology RM1-950 Xiangrui Yang Shichao Wu N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke
description	Causing more and more deaths, stroke has been a leading cause of death worldwide. However, success in clinical stroke trials has remained elusive. N-oleoylethanolamine (OEA) was an endogenous highly hydrophobic molecule with outstanding neuroprotective effect. In this article, hydrogen bonds were successfully formed between OEA and soybean phosphatidylcholine (SPC). The synthetic OEA-SPC complex and DSPE-PEG were self-assembled into liposomes (OEA NPs), with OEA-SPC loaded in the core and PEG formed a hydrophilic shell. Hence, highly hydrophobic OEA was loaded into liposomes as amorphous state with a drug loading of 8.21 ± 0.18 wt%. With fairly uniform size and well-distributed character, the OEA NPs were systemically assessed as an intravenous formulation for stroke therapy. The results indicated that the administration of OEA NPs could significantly improve the survival rate and the Garcia score of the MCAO rats compared with free OEA. The TTC-stained brain slices declared that the cerebral infarct volume and the edema degree induced by MCAO could be decreased to an extremely low level via the administration of OEA NPs. The Morris water maze (MWM) test suggested that the spatial learning and memory of the MCAO rats could also be ameliorated by OEA NPs. The immunofluorescence assay stated that the apoptosis of the neurons and the inflammation within the brain were greatly inhibited. The results suggest that the OEA NPs have a great chance to develop OEA as a potential anti-stroke formulation for clinic application.
format	article
author	Xiangrui Yang Shichao Wu
author_facet	Xiangrui Yang Shichao Wu
author_sort	Xiangrui Yang
title	N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke
title_short	N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke
title_full	N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke
title_fullStr	N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke
title_full_unstemmed	N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke
title_sort	n-oleoylethanolamine − phosphatidylcholine complex loaded, dspe-peg integrated liposomes for efficient stroke
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/a81f59bc04eb4fedbe68e5bf37b5aecc
work_keys_str_mv	AT xiangruiyang noleoylethanolaminephosphatidylcholinecomplexloadeddspepegintegratedliposomesforefficientstroke AT shichaowu noleoylethanolaminephosphatidylcholinecomplexloadeddspepegintegratedliposomesforefficientstroke
_version_	1718405012448608256

N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke

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