The advantage of arriving first: characteristic times in finite size populations of error-prone replicators.

We study the evolution of a finite size population formed by mutationally isolated lineages of error-prone replicators in a two-peak fitness landscape. Computer simulations are performed to gain a stochastic description of the system dynamics. More specifically, for different population sizes, we co...

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Autores principales: Arturo Marín, Héctor Tejero, Juan Carlos Nuño, Francisco Montero
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Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/a821dd2b10e34f5f95cb7c0a01c51f9b
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spelling oai:doaj.org-article:a821dd2b10e34f5f95cb7c0a01c51f9b2021-11-18T08:40:38ZThe advantage of arriving first: characteristic times in finite size populations of error-prone replicators.1932-620310.1371/journal.pone.0083142https://doaj.org/article/a821dd2b10e34f5f95cb7c0a01c51f9b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24376656/?tool=EBIhttps://doaj.org/toc/1932-6203We study the evolution of a finite size population formed by mutationally isolated lineages of error-prone replicators in a two-peak fitness landscape. Computer simulations are performed to gain a stochastic description of the system dynamics. More specifically, for different population sizes, we compute the probability of each lineage being selected in terms of their mutation rates and the amplification factors of the fittest phenotypes. We interpret the results as the compromise between the characteristic time a lineage takes to reach its fittest phenotype by crossing the neutral valley and the selective value of the sequences that form the lineages. A main conclusion is drawn: for finite population sizes, the survival probability of the lineage that arrives first to the fittest phenotype rises significantly.Arturo MarínHéctor TejeroJuan Carlos NuñoFrancisco MonteroPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83142 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Arturo Marín
Héctor Tejero
Juan Carlos Nuño
Francisco Montero
The advantage of arriving first: characteristic times in finite size populations of error-prone replicators.
description We study the evolution of a finite size population formed by mutationally isolated lineages of error-prone replicators in a two-peak fitness landscape. Computer simulations are performed to gain a stochastic description of the system dynamics. More specifically, for different population sizes, we compute the probability of each lineage being selected in terms of their mutation rates and the amplification factors of the fittest phenotypes. We interpret the results as the compromise between the characteristic time a lineage takes to reach its fittest phenotype by crossing the neutral valley and the selective value of the sequences that form the lineages. A main conclusion is drawn: for finite population sizes, the survival probability of the lineage that arrives first to the fittest phenotype rises significantly.
format article
author Arturo Marín
Héctor Tejero
Juan Carlos Nuño
Francisco Montero
author_facet Arturo Marín
Héctor Tejero
Juan Carlos Nuño
Francisco Montero
author_sort Arturo Marín
title The advantage of arriving first: characteristic times in finite size populations of error-prone replicators.
title_short The advantage of arriving first: characteristic times in finite size populations of error-prone replicators.
title_full The advantage of arriving first: characteristic times in finite size populations of error-prone replicators.
title_fullStr The advantage of arriving first: characteristic times in finite size populations of error-prone replicators.
title_full_unstemmed The advantage of arriving first: characteristic times in finite size populations of error-prone replicators.
title_sort advantage of arriving first: characteristic times in finite size populations of error-prone replicators.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/a821dd2b10e34f5f95cb7c0a01c51f9b
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