A retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%

Yael Kusne,1 Paul Kang,1 Robert E Fintelmann1,2 1University of Arizona College of Medicine–Phoenix, 2Barnet Dulaney Perkins Eye Center, Phoenix, AZ, USA Purpose: To compare the effect of topical prednisolone acetate 1% (PA) used after routine cataract surgery to the effect of diflupredna...

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Autores principales:	Kusne Y, Kang P, Fintelmann RE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	intra-ocular pressure cataract surgery steroid responder glaucoma Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a823c9099696471cb030f35f4036790c
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spelling	oai:doaj.org-article:a823c9099696471cb030f35f4036790c2021-12-02T06:55:38ZA retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%1177-5483https://doaj.org/article/a823c9099696471cb030f35f4036790c2016-11-01T00:00:00Zhttps://www.dovepress.com/a-retrospective-analysis-of-intraocular-pressure-changes-after-catarac-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yael Kusne,1 Paul Kang,1 Robert E Fintelmann1,2 1University of Arizona College of Medicine–Phoenix, 2Barnet Dulaney Perkins Eye Center, Phoenix, AZ, USA Purpose: To compare the effect of topical prednisolone acetate 1% (PA) used after routine cataract surgery to the effect of difluprednate 0.05% (DFBA) used for the same indication on intraocular pressure (IOP).Methods: An electronic query was created to gather information from all cataract surgeries between January 2010 and January 2015 within the electronic health record database at Barnet Dulaney Perkins, a multicenter, multiphysician private practice in Phoenix, Arizona. Information collected included age, sex, diabetes status, glaucoma history, medication regimen (use of PA or DFBA), and IOP before surgery, 5–10 days postoperatively (TP1) and 3–6 weeks postoperatively (TP2). Postoperative IOP measurements were compared to baseline IOP measurement in each patient.Results: Regardless of steroid used, all patients in this study experienced an increase in IOP within TP1 and returned to baseline IOP (±2.0 mmHg) by TP2. Patients who received DFBA showed a statistically significant increase in IOP at TP1 compared to those on PA (P<0.001) with the mean IOP an average 0.60 mmHg higher (95% CI =0.3, 0.9). The odds ratio of a clinically significantly increased IOP at TP1 (defined as overall IOP ≥21 mmHg and an increase of ≥10 mmHg) in DFBA-treated patients was 1.84 (95% CI =1.4, 2.6). In patients treated with PA, 3% reached a significantly increased IOP, compared to 4.4% of patients in the DFBA group (P<0.05). Risk factors for increased IOP were identified, and include advanced age (>75) (P<0.005) and a history of glaucoma (P<0.001).Conclusion: In postoperative cataract patients, use of DFBA increased the risk of a clinically significant IOP increase. Keywords: intraocular pressure, cataract surgery, steroid responder, glaucomaKusne YKang PFintelmann REDove Medical Pressarticleintra-ocular pressurecataract surgerysteroid responderglaucomaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 2329-2336 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	intra-ocular pressure cataract surgery steroid responder glaucoma Ophthalmology RE1-994
spellingShingle	intra-ocular pressure cataract surgery steroid responder glaucoma Ophthalmology RE1-994 Kusne Y Kang P Fintelmann RE A retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%
description	Yael Kusne,1 Paul Kang,1 Robert E Fintelmann1,2 1University of Arizona College of Medicine–Phoenix, 2Barnet Dulaney Perkins Eye Center, Phoenix, AZ, USA Purpose: To compare the effect of topical prednisolone acetate 1% (PA) used after routine cataract surgery to the effect of difluprednate 0.05% (DFBA) used for the same indication on intraocular pressure (IOP).Methods: An electronic query was created to gather information from all cataract surgeries between January 2010 and January 2015 within the electronic health record database at Barnet Dulaney Perkins, a multicenter, multiphysician private practice in Phoenix, Arizona. Information collected included age, sex, diabetes status, glaucoma history, medication regimen (use of PA or DFBA), and IOP before surgery, 5–10 days postoperatively (TP1) and 3–6 weeks postoperatively (TP2). Postoperative IOP measurements were compared to baseline IOP measurement in each patient.Results: Regardless of steroid used, all patients in this study experienced an increase in IOP within TP1 and returned to baseline IOP (±2.0 mmHg) by TP2. Patients who received DFBA showed a statistically significant increase in IOP at TP1 compared to those on PA (P<0.001) with the mean IOP an average 0.60 mmHg higher (95% CI =0.3, 0.9). The odds ratio of a clinically significantly increased IOP at TP1 (defined as overall IOP ≥21 mmHg and an increase of ≥10 mmHg) in DFBA-treated patients was 1.84 (95% CI =1.4, 2.6). In patients treated with PA, 3% reached a significantly increased IOP, compared to 4.4% of patients in the DFBA group (P<0.05). Risk factors for increased IOP were identified, and include advanced age (>75) (P<0.005) and a history of glaucoma (P<0.001).Conclusion: In postoperative cataract patients, use of DFBA increased the risk of a clinically significant IOP increase. Keywords: intraocular pressure, cataract surgery, steroid responder, glaucoma
format	article
author	Kusne Y Kang P Fintelmann RE
author_facet	Kusne Y Kang P Fintelmann RE
author_sort	Kusne Y
title	A retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%
title_short	A retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%
title_full	A retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%
title_fullStr	A retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%
title_full_unstemmed	A retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%
title_sort	retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a823c9099696471cb030f35f4036790c
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A retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%

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