A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.

<h4>Background</h4>A common genetic variant, rs4939827, located in SMAD7, was identified by two recent genome-wide association (GWA) studies to be strongly associated with the risk of colorectal cancer (CRC). However, the following replication studies yielded conflicting results.<h4&g...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Qibin Song, Beibei Zhu, Weiguo Hu, Liming Cheng, Hongyun Gong, Bin Xu, Xiawen Zheng, Li Zou, Rong Zhong, Shengyu Duan, Wei Chen, Rui Rui, Jing Wu, Xiaoping Miao
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
R
Q
Acceso en línea:https://doaj.org/article/a82420e3b2454fd089c66fb586b590cf
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a82420e3b2454fd089c66fb586b590cf
record_format dspace
spelling oai:doaj.org-article:a82420e3b2454fd089c66fb586b590cf2021-11-18T07:24:36ZA common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.1932-620310.1371/journal.pone.0033318https://doaj.org/article/a82420e3b2454fd089c66fb586b590cf2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22457752/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A common genetic variant, rs4939827, located in SMAD7, was identified by two recent genome-wide association (GWA) studies to be strongly associated with the risk of colorectal cancer (CRC). However, the following replication studies yielded conflicting results.<h4>Method and findings</h4>We conducted a case-control study of 641 cases and 1037 controls in a Chinese population and then performed a meta-analysis, integrating our and published data of 34313 cases and 33251 controls, to clarify the relationship between rs4939827 and CRC risk. In our case-control study, the dominant model was significant associated with increased CRC risk [Odds Ratio (OR) = 1.46; 95% confidence interval (95% CI), 1.19-1.80]. The following meta-analysis further confirmed this significant association for all genetic models but with significant between-study heterogeneity (all P for heterogeneity <0.1). By stratified analysis, we revealed that ethnicity, sample size, and tumor sites might constitute the source of heterogeneity. The cumulative analysis suggested that evident tendency to significant association was seen with adding study samples over time; whilst, sensitive analysis showed results before and after removal of each study were similar, indicating the highly stability of the current results.<h4>Conclusion</h4>Results from our case-control study and the meta-analysis collectively confirmed the significant association of the variant rs4939827 with increased risk of colorectal cancer. Nevertheless, fine-mapping of the susceptibility loci defined by rs4939287 should be imposed to reveal causal variant.Qibin SongBeibei ZhuWeiguo HuLiming ChengHongyun GongBin XuXiawen ZhengLi ZouRong ZhongShengyu DuanWei ChenRui RuiJing WuXiaoping MiaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33318 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Qibin Song
Beibei Zhu
Weiguo Hu
Liming Cheng
Hongyun Gong
Bin Xu
Xiawen Zheng
Li Zou
Rong Zhong
Shengyu Duan
Wei Chen
Rui Rui
Jing Wu
Xiaoping Miao
A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.
description <h4>Background</h4>A common genetic variant, rs4939827, located in SMAD7, was identified by two recent genome-wide association (GWA) studies to be strongly associated with the risk of colorectal cancer (CRC). However, the following replication studies yielded conflicting results.<h4>Method and findings</h4>We conducted a case-control study of 641 cases and 1037 controls in a Chinese population and then performed a meta-analysis, integrating our and published data of 34313 cases and 33251 controls, to clarify the relationship between rs4939827 and CRC risk. In our case-control study, the dominant model was significant associated with increased CRC risk [Odds Ratio (OR) = 1.46; 95% confidence interval (95% CI), 1.19-1.80]. The following meta-analysis further confirmed this significant association for all genetic models but with significant between-study heterogeneity (all P for heterogeneity <0.1). By stratified analysis, we revealed that ethnicity, sample size, and tumor sites might constitute the source of heterogeneity. The cumulative analysis suggested that evident tendency to significant association was seen with adding study samples over time; whilst, sensitive analysis showed results before and after removal of each study were similar, indicating the highly stability of the current results.<h4>Conclusion</h4>Results from our case-control study and the meta-analysis collectively confirmed the significant association of the variant rs4939827 with increased risk of colorectal cancer. Nevertheless, fine-mapping of the susceptibility loci defined by rs4939287 should be imposed to reveal causal variant.
format article
author Qibin Song
Beibei Zhu
Weiguo Hu
Liming Cheng
Hongyun Gong
Bin Xu
Xiawen Zheng
Li Zou
Rong Zhong
Shengyu Duan
Wei Chen
Rui Rui
Jing Wu
Xiaoping Miao
author_facet Qibin Song
Beibei Zhu
Weiguo Hu
Liming Cheng
Hongyun Gong
Bin Xu
Xiawen Zheng
Li Zou
Rong Zhong
Shengyu Duan
Wei Chen
Rui Rui
Jing Wu
Xiaoping Miao
author_sort Qibin Song
title A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.
title_short A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.
title_full A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.
title_fullStr A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.
title_full_unstemmed A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.
title_sort common smad7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/a82420e3b2454fd089c66fb586b590cf
work_keys_str_mv AT qibinsong acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT beibeizhu acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT weiguohu acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT limingcheng acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT hongyungong acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT binxu acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT xiawenzheng acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT lizou acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT rongzhong acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT shengyuduan acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT weichen acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT ruirui acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT jingwu acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT xiaopingmiao acommonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT qibinsong commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT beibeizhu commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT weiguohu commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT limingcheng commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT hongyungong commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT binxu commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT xiawenzheng commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT lizou commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT rongzhong commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT shengyuduan commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT weichen commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT ruirui commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT jingwu commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
AT xiaopingmiao commonsmad7variantisassociatedwithriskofcolorectalcancerevidencefromacasecontrolstudyandametaanalysis
_version_ 1718423493511479296