ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function

CTCF mediates DNA–DNA interactions by forming dimers that directly bind to both sides of the DNA. Here the authors reveal that a CTCF known associated zinc finger, ZNF143, mediates gene transcription through CTCF–DNA binding to maintain murine hematopoietic stem and progenitor cell integrity.

Guardado en:

Detalles Bibliográficos
Autores principales:	Qiling Zhou, Miao Yu, Roberto Tirado-Magallanes, Bin Li, Lingshi Kong, Mingrui Guo, Zi Hui Tan, Sanghoon Lee, Li Chai, Akihiko Numata, Touati Benoukraf, Melissa Jane Fullwood, Motomi Osato, Bing Ren, Daniel G. Tenen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a828711a0de141af954d80bfa7285356
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a828711a0de141af954d80bfa7285356
record_format	dspace
spelling	oai:doaj.org-article:a828711a0de141af954d80bfa72853562021-12-02T11:45:56ZZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function10.1038/s41467-020-20282-12041-1723https://doaj.org/article/a828711a0de141af954d80bfa72853562021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20282-1https://doaj.org/toc/2041-1723CTCF mediates DNA–DNA interactions by forming dimers that directly bind to both sides of the DNA. Here the authors reveal that a CTCF known associated zinc finger, ZNF143, mediates gene transcription through CTCF–DNA binding to maintain murine hematopoietic stem and progenitor cell integrity.Qiling ZhouMiao YuRoberto Tirado-MagallanesBin LiLingshi KongMingrui GuoZi Hui TanSanghoon LeeLi ChaiAkihiko NumataTouati BenoukrafMelissa Jane FullwoodMotomi OsatoBing RenDaniel G. TenenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiling Zhou Miao Yu Roberto Tirado-Magallanes Bin Li Lingshi Kong Mingrui Guo Zi Hui Tan Sanghoon Lee Li Chai Akihiko Numata Touati Benoukraf Melissa Jane Fullwood Motomi Osato Bing Ren Daniel G. Tenen ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
description	CTCF mediates DNA–DNA interactions by forming dimers that directly bind to both sides of the DNA. Here the authors reveal that a CTCF known associated zinc finger, ZNF143, mediates gene transcription through CTCF–DNA binding to maintain murine hematopoietic stem and progenitor cell integrity.
format	article
author	Qiling Zhou Miao Yu Roberto Tirado-Magallanes Bin Li Lingshi Kong Mingrui Guo Zi Hui Tan Sanghoon Lee Li Chai Akihiko Numata Touati Benoukraf Melissa Jane Fullwood Motomi Osato Bing Ren Daniel G. Tenen
author_facet	Qiling Zhou Miao Yu Roberto Tirado-Magallanes Bin Li Lingshi Kong Mingrui Guo Zi Hui Tan Sanghoon Lee Li Chai Akihiko Numata Touati Benoukraf Melissa Jane Fullwood Motomi Osato Bing Ren Daniel G. Tenen
author_sort	Qiling Zhou
title	ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
title_short	ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
title_full	ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
title_fullStr	ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
title_full_unstemmed	ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
title_sort	znf143 mediates ctcf-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a828711a0de141af954d80bfa7285356
work_keys_str_mv	AT qilingzhou znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT miaoyu znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT robertotiradomagallanes znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT binli znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT lingshikong znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT mingruiguo znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT zihuitan znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT sanghoonlee znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT lichai znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT akihikonumata znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT touatibenoukraf znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT melissajanefullwood znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT motomiosato znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT bingren znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction AT danielgtenen znf143mediatesctcfboundpromoterenhancerloopsrequiredformurinehematopoieticstemandprogenitorcellfunction
_version_	1718395245483261952

ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function

Ejemplares similares