Mechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.

Bacteria develop resistance to antimicrobial agents by a number of different mechanisms. The resistance to (fluoro)quinolones in Salmonella is of particular importance especially if therapy in humans is required. For decades there has been a significant interest in studying the biology of Salmonella...

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Autor principal:	Velhner Maja
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	salmonella resistance quinolones efflux pump pmqr Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/a82b83b3cf7842b088071a2c9acd4fbc
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spelling	oai:doaj.org-article:a82b83b3cf7842b088071a2c9acd4fbc2021-11-17T21:27:51ZMechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.1820-744810.1515/acve-2016-0013https://doaj.org/article/a82b83b3cf7842b088071a2c9acd4fbc2016-06-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0013https://doaj.org/toc/1820-7448Bacteria develop resistance to antimicrobial agents by a number of different mechanisms. The resistance to (fluoro)quinolones in Salmonella is of particular importance especially if therapy in humans is required. For decades there has been a significant interest in studying the biology of Salmonella because these bacteria are among the leading causes of foodborne illnesses around the globe. To this date, two main mechanisms of quinolone resistance have been established: alteration in the targets for quinolones, decreased accumulation inside bacteria due to impermeability of the membrane and/or an over expression of the efflux pump systems. Both of these mechanisms are chromosomally mediated. Furthermore, mobile elements have been described carrying the qnr gene which confers resistance to quinolones. The plasmid encoded QNR proteins belong to the pentapeptide repeat family of proteins. The plasmid mediated quinolone resistance (PMQR) is often associated with the resistance to beta lactam antibiotics. It was noticed that PMQR is backing up chromosomal mutations for quinolone resistance, hence becoming an important resistance mechanism worldwide. Even with our knowledge expanding over the years, it is not possible to predict how bacteria will respond in the future, if they are exposed to new external challenges. The possibility that they will find a way to survive by introducing new mutations or by exchanging mobile genetic elements and subsequently developing resistance to survive in the environment should not be underestimated.Velhner MajaSciendoarticlesalmonellaresistancequinolonesefflux pumppmqrVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 2, Pp 147-159 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	salmonella resistance quinolones efflux pump pmqr Veterinary medicine SF600-1100
spellingShingle	salmonella resistance quinolones efflux pump pmqr Veterinary medicine SF600-1100 Velhner Maja Mechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.
description	Bacteria develop resistance to antimicrobial agents by a number of different mechanisms. The resistance to (fluoro)quinolones in Salmonella is of particular importance especially if therapy in humans is required. For decades there has been a significant interest in studying the biology of Salmonella because these bacteria are among the leading causes of foodborne illnesses around the globe. To this date, two main mechanisms of quinolone resistance have been established: alteration in the targets for quinolones, decreased accumulation inside bacteria due to impermeability of the membrane and/or an over expression of the efflux pump systems. Both of these mechanisms are chromosomally mediated. Furthermore, mobile elements have been described carrying the qnr gene which confers resistance to quinolones. The plasmid encoded QNR proteins belong to the pentapeptide repeat family of proteins. The plasmid mediated quinolone resistance (PMQR) is often associated with the resistance to beta lactam antibiotics. It was noticed that PMQR is backing up chromosomal mutations for quinolone resistance, hence becoming an important resistance mechanism worldwide. Even with our knowledge expanding over the years, it is not possible to predict how bacteria will respond in the future, if they are exposed to new external challenges. The possibility that they will find a way to survive by introducing new mutations or by exchanging mobile genetic elements and subsequently developing resistance to survive in the environment should not be underestimated.
format	article
author	Velhner Maja
author_facet	Velhner Maja
author_sort	Velhner Maja
title	Mechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.
title_short	Mechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.
title_full	Mechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.
title_fullStr	Mechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.
title_full_unstemmed	Mechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.
title_sort	mechanisms of resistance to quinolones and epidemiological significance of salmonella spp.
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/a82b83b3cf7842b088071a2c9acd4fbc
work_keys_str_mv	AT velhnermaja mechanismsofresistancetoquinolonesandepidemiologicalsignificanceofsalmonellaspp
_version_	1718425305283035136

Mechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.

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