The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing

Sensory perception and metabolic homeostasis are known to deteriorate with ageing, while mechanisms underlying their deterioration remain poorly understood. Here, the authors demonstrate that decrease of intraflagellar transport in the cilia of sensory neurons impairs sensory perception and metaboli...

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Bibliographic Details
Main Authors: Yincong Zhang, Xiaona Zhang, Yumin Dai, Mengjiao Song, Yifei Zhou, Jun Zhou, Xiumin Yan, Yidong Shen
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/a82d93d3e87543e6aedec0ff934e99cf
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Summary:Sensory perception and metabolic homeostasis are known to deteriorate with ageing, while mechanisms underlying their deterioration remain poorly understood. Here, the authors demonstrate that decrease of intraflagellar transport in the cilia of sensory neurons impairs sensory perception and metabolism in ageing C. elegans.