Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway

Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell phenotype and promote doxorubicin resistance in p...

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Autores principales:	Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b
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spelling	oai:doaj.org-article:a82e2a88c87b4da18c5103c84eb99f0b2021-12-02T10:49:14ZDll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway10.1038/s41467-020-20664-52041-1723https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20664-5https://doaj.org/toc/2041-1723Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell phenotype and promote doxorubicin resistance in part through NF-kB, as well as metastasis.Sushil KumarAjeya NandiSnahlata SinghRohan RegulapatiNing LiJohn W. TobiasChristian W. SiebelMario Andres BlancoAndres J. Klein-SzantoChristopher LengnerAlana L. WelmYibin KangRumela ChakrabartiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sushil Kumar Ajeya Nandi Snahlata Singh Rohan Regulapati Ning Li John W. Tobias Christian W. Siebel Mario Andres Blanco Andres J. Klein-Szanto Christopher Lengner Alana L. Welm Yibin Kang Rumela Chakrabarti Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway
description	Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell phenotype and promote doxorubicin resistance in part through NF-kB, as well as metastasis.
format	article
author	Sushil Kumar Ajeya Nandi Snahlata Singh Rohan Regulapati Ning Li John W. Tobias Christian W. Siebel Mario Andres Blanco Andres J. Klein-Szanto Christopher Lengner Alana L. Welm Yibin Kang Rumela Chakrabarti
author_facet	Sushil Kumar Ajeya Nandi Snahlata Singh Rohan Regulapati Ning Li John W. Tobias Christian W. Siebel Mario Andres Blanco Andres J. Klein-Szanto Christopher Lengner Alana L. Welm Yibin Kang Rumela Chakrabarti
author_sort	Sushil Kumar
title	Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway
title_short	Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway
title_full	Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway
title_fullStr	Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway
title_full_unstemmed	Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway
title_sort	dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through nf-κb survival pathway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b
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Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway

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