The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis

PurposeSleep duration is thought to play a key role in the development of metabolic syndrome. However, the results have been inconsistent.MethodsWe conducted a systematic review and meta-analysis of cohort studies and searched publications in PubMed, Embase, Cochrane Central Register of Controlled T...

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Autores principales:	Tingting Che, Cheng Yan, Dingyuan Tian, Xin Zhang, Xuejun Liu, Zhongming Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sleep duration metabolic syndrome meta-analysis obesity diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/a82e38eda71d4d12baaf8897951f1f49
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spelling	oai:doaj.org-article:a82e38eda71d4d12baaf8897951f1f492021-11-19T07:30:19ZThe Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis1664-239210.3389/fendo.2021.773646https://doaj.org/article/a82e38eda71d4d12baaf8897951f1f492021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.773646/fullhttps://doaj.org/toc/1664-2392PurposeSleep duration is thought to play a key role in the development of metabolic syndrome. However, the results have been inconsistent.MethodsWe conducted a systematic review and meta-analysis of cohort studies and searched publications in PubMed, Embase, Cochrane Central Register of Controlled Trials, and Clinicaltrials.gov. The summary relative risks (RRs) were estimated using a random model. The sensitivity analysis was performed by sequentially excluding each study to test the robustness of the pooled estimates.FindingWe included 13 studies involving 300,202 patients in which short sleep and long sleep significantly increased the risk of metabolic syndrome 15% (RR = 1.15, 95%CI = 1.09-1.22, p < 0.001) and 19% (RR = 1.19, 95%CI = 1.05-1.35, p < 0.001). Moreover, the relationship between sleep duration and metabolic syndrome risk presented a U-shaped curve. Short and long sleep increased the risk of obesity by 14% (RR = 1.14, 95%CI = 1.07-1.22, p<0.001) and 15% (RR = 1.15, 95%CI = 1.00-1.30, p = 0.04), and high blood pressure 16% (RR = 1.16, 95%CI = 1.02-1.31, p = 0.03) and 13% (RR = 1.13, 95%CI = 1.04-1.24, p = 0.01), respectively. Short sleep can potentially increase the risk of high blood sugar by 12% (RR = 1.12, 95%CI = 1.00-1.15, P = 0.05).ImplicationsBased on our findings, sleep is a behavior that can be changed and is economical. Clinically doctors and health professionals should be encouraged to increase their efforts to promote healthy sleep for all people.Tingting CheCheng YanDingyuan TianXin ZhangXuejun LiuZhongming WuFrontiers Media S.A.articlesleep durationmetabolic syndromemeta-analysisobesitydiabetesDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep duration metabolic syndrome meta-analysis obesity diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	sleep duration metabolic syndrome meta-analysis obesity diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665 Tingting Che Cheng Yan Dingyuan Tian Xin Zhang Xuejun Liu Zhongming Wu The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis
description	PurposeSleep duration is thought to play a key role in the development of metabolic syndrome. However, the results have been inconsistent.MethodsWe conducted a systematic review and meta-analysis of cohort studies and searched publications in PubMed, Embase, Cochrane Central Register of Controlled Trials, and Clinicaltrials.gov. The summary relative risks (RRs) were estimated using a random model. The sensitivity analysis was performed by sequentially excluding each study to test the robustness of the pooled estimates.FindingWe included 13 studies involving 300,202 patients in which short sleep and long sleep significantly increased the risk of metabolic syndrome 15% (RR = 1.15, 95%CI = 1.09-1.22, p < 0.001) and 19% (RR = 1.19, 95%CI = 1.05-1.35, p < 0.001). Moreover, the relationship between sleep duration and metabolic syndrome risk presented a U-shaped curve. Short and long sleep increased the risk of obesity by 14% (RR = 1.14, 95%CI = 1.07-1.22, p<0.001) and 15% (RR = 1.15, 95%CI = 1.00-1.30, p = 0.04), and high blood pressure 16% (RR = 1.16, 95%CI = 1.02-1.31, p = 0.03) and 13% (RR = 1.13, 95%CI = 1.04-1.24, p = 0.01), respectively. Short sleep can potentially increase the risk of high blood sugar by 12% (RR = 1.12, 95%CI = 1.00-1.15, P = 0.05).ImplicationsBased on our findings, sleep is a behavior that can be changed and is economical. Clinically doctors and health professionals should be encouraged to increase their efforts to promote healthy sleep for all people.
format	article
author	Tingting Che Cheng Yan Dingyuan Tian Xin Zhang Xuejun Liu Zhongming Wu
author_facet	Tingting Che Cheng Yan Dingyuan Tian Xin Zhang Xuejun Liu Zhongming Wu
author_sort	Tingting Che
title	The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis
title_short	The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis
title_full	The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis
title_fullStr	The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis
title_full_unstemmed	The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis
title_sort	association between sleep and metabolic syndrome: a systematic review and meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a82e38eda71d4d12baaf8897951f1f49
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The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis

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