Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review

Alzheimer’s disease (AD) is a heterogeneous degenerative brain disorder with a rising prevalence worldwide. The two hallmarks that characterize the AD pathophysiology are amyloid plaques, generated via aggregated amyloid β, and neurofibrillary tangle, generated via accumulated phosphorylated tau. At...

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Autores principales:	Hani Sabaie, Nazanin Amirinejad, Mohammad Reza Asadi, Abbas Jalaiei, Yousef Daneshmandpour, Omidvar Rezaei, Mohammad Taheri, Maryam Rezazadeh
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Alzheimer’s disease antisense oligonucleotides competing endogenous RNA long non-coding RNA miRNA sponge Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/a83098d4e64344e19aa3f308ce936fb7
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spelling	oai:doaj.org-article:a83098d4e64344e19aa3f308ce936fb72021-12-01T01:31:09ZMolecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review1663-436510.3389/fnagi.2021.742242https://doaj.org/article/a83098d4e64344e19aa3f308ce936fb72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.742242/fullhttps://doaj.org/toc/1663-4365Alzheimer’s disease (AD) is a heterogeneous degenerative brain disorder with a rising prevalence worldwide. The two hallmarks that characterize the AD pathophysiology are amyloid plaques, generated via aggregated amyloid β, and neurofibrillary tangle, generated via accumulated phosphorylated tau. At the post-transcriptional and transcriptional levels, the regulatory functions of non-coding RNAs, in particular long non-coding RNAs (lncRNAs), have been ascertained in gene expressions. It is noteworthy that a number of lncRNAs feature a prevalent role in their potential of regulating gene expression through modulation of microRNAs via a process called the mechanism of competing endogenous RNA (ceRNA). Given the multifactorial nature of ceRNA interaction networks, they might be advantageous in complex disorders (e.g., AD) investigations at the therapeutic targets level. We carried out scoping review in this research to analyze validated loops of ceRNA in AD and focus on ceRNA axes associated with lncRNA. This scoping review was performed according to a six-stage methodology structure and PRISMA guideline. A systematic search of seven databases was conducted to find eligible articles prior to July 2021. Two reviewers independently performed publications screening and data extraction, and quantitative and qualitative analyses were conducted. Fourteen articles were identified that fulfill the inclusion criteria. Studies with different designs reported nine lncRNAs that were experimentally validated to act as ceRNA in AD in human-related studies, including BACE1-AS, SNHG1, RPPH1, NEAT1, LINC00094, SOX21-AS1, LINC00507, MAGI2-AS3, and LINC01311. The BACE1-AS/BACE1 was the most frequent ceRNA pair. Among miRNAs, miR-107 played a key role by regulating three different loops. Understanding the various aspects of this regulatory mechanism can help elucidate the unknown etiology of AD and provide new molecular targets for use in therapeutic and clinical applications.Hani SabaieHani SabaieNazanin AmirinejadMohammad Reza AsadiAbbas JalaieiYousef DaneshmandpourOmidvar RezaeiMohammad TaheriMohammad TaheriMaryam RezazadehMaryam RezazadehFrontiers Media S.A.articleAlzheimer’s diseaseantisense oligonucleotidescompeting endogenous RNAlong non-coding RNAmiRNA spongeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease antisense oligonucleotides competing endogenous RNA long non-coding RNA miRNA sponge Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Alzheimer’s disease antisense oligonucleotides competing endogenous RNA long non-coding RNA miRNA sponge Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Hani Sabaie Hani Sabaie Nazanin Amirinejad Mohammad Reza Asadi Abbas Jalaiei Yousef Daneshmandpour Omidvar Rezaei Mohammad Taheri Mohammad Taheri Maryam Rezazadeh Maryam Rezazadeh Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review
description	Alzheimer’s disease (AD) is a heterogeneous degenerative brain disorder with a rising prevalence worldwide. The two hallmarks that characterize the AD pathophysiology are amyloid plaques, generated via aggregated amyloid β, and neurofibrillary tangle, generated via accumulated phosphorylated tau. At the post-transcriptional and transcriptional levels, the regulatory functions of non-coding RNAs, in particular long non-coding RNAs (lncRNAs), have been ascertained in gene expressions. It is noteworthy that a number of lncRNAs feature a prevalent role in their potential of regulating gene expression through modulation of microRNAs via a process called the mechanism of competing endogenous RNA (ceRNA). Given the multifactorial nature of ceRNA interaction networks, they might be advantageous in complex disorders (e.g., AD) investigations at the therapeutic targets level. We carried out scoping review in this research to analyze validated loops of ceRNA in AD and focus on ceRNA axes associated with lncRNA. This scoping review was performed according to a six-stage methodology structure and PRISMA guideline. A systematic search of seven databases was conducted to find eligible articles prior to July 2021. Two reviewers independently performed publications screening and data extraction, and quantitative and qualitative analyses were conducted. Fourteen articles were identified that fulfill the inclusion criteria. Studies with different designs reported nine lncRNAs that were experimentally validated to act as ceRNA in AD in human-related studies, including BACE1-AS, SNHG1, RPPH1, NEAT1, LINC00094, SOX21-AS1, LINC00507, MAGI2-AS3, and LINC01311. The BACE1-AS/BACE1 was the most frequent ceRNA pair. Among miRNAs, miR-107 played a key role by regulating three different loops. Understanding the various aspects of this regulatory mechanism can help elucidate the unknown etiology of AD and provide new molecular targets for use in therapeutic and clinical applications.
format	article
author	Hani Sabaie Hani Sabaie Nazanin Amirinejad Mohammad Reza Asadi Abbas Jalaiei Yousef Daneshmandpour Omidvar Rezaei Mohammad Taheri Mohammad Taheri Maryam Rezazadeh Maryam Rezazadeh
author_facet	Hani Sabaie Hani Sabaie Nazanin Amirinejad Mohammad Reza Asadi Abbas Jalaiei Yousef Daneshmandpour Omidvar Rezaei Mohammad Taheri Mohammad Taheri Maryam Rezazadeh Maryam Rezazadeh
author_sort	Hani Sabaie
title	Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review
title_short	Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review
title_full	Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review
title_fullStr	Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review
title_full_unstemmed	Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review
title_sort	molecular insight into the therapeutic potential of long non-coding rna-associated competing endogenous rna axes in alzheimer’s disease: a systematic scoping review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a83098d4e64344e19aa3f308ce936fb7
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Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review

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