$Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects$
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Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects

George Kymionis,1 George Kontadakis,1,2 Michael Grentzelos,1 Myrsini Petrelli1 1Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland; 2Laboratory of Vision and Optics, University of Crete, Heraklion, GreeceCorrespondence:...

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Autores principales:	Kymionis G, Kontadakis G, Grentzelos M, Petrelli M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	corneal crosslinking photorefractive keratoplasty forme fruste keratoconus corneal topography irregular astigmatism Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a830c44df4734b019968bae913d82e5a
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spelling	oai:doaj.org-article:a830c44df4734b019968bae913d82e5a2021-12-02T15:47:50ZLong-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects1177-5483https://doaj.org/article/a830c44df4734b019968bae913d82e5a2021-06-01T00:00:00Zhttps://www.dovepress.com/long-term-follow-up-of-combined-photorefractive-keratectomy-and-cornea-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483George Kymionis,1 George Kontadakis,1,2 Michael Grentzelos,1 Myrsini Petrelli1 1Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland; 2Laboratory of Vision and Optics, University of Crete, Heraklion, GreeceCorrespondence: George KontadakisLaboratory of Vision and Optics, University of Crete, Heraklion, GreeceEmail kontadas@yahoo.comPurpose: To present the long-term outcomes of photorefractive keratectomy (PRK) combined with accelerated corneal cross-linking (CXL) for refractive error correction in a series of keratoconus suspects.Setting: University practice.Design: Retrospective case series.Methods: A series of patients with topographic findings suspicious for keratoconus underwent simultaneous PRK and prophylactic accelerated CXL (5 minutes with intensity of 18 mW/cm2) for the correction of their refractive error. The results were recorded for more than 4 years postoperatively.Results: Ten eyes of 5 patients were included. Mean follow-up was 58.2 months (range from 54 to 62 months). Mean age at presentation was 25 years (range from 22 to 32 years). Mean spherical equivalent (SE) refraction was − 2.76 (standard deviation [SD] 0.97D, range from − 1.25 to − 4.00 diopters [D]), while mean central corneal thickness was 511μm (SD 13μm, range from 485 to 536 μm). At last, follow-up 9 out of 10 eyes had SE refraction within ± 0.50D and all eyes had SE within ± 1.00D. None of the eyes lost any line of corrected distance visual acuity (CDVA), whereas 1 eye gained one line of CDVA. All eyes demonstrated stability of their results during the follow-up period.Conclusion: Simultaneous PRK followed by prophylactic accelerated CXL (PRK plus) appeared to be a safe and effective option for the correction of the refractive error in this series of keratoconus suspect patients, without compromising corneal stability for up to 5 years postoperatively.Keywords: corneal crosslinking, photorefractive keratoplasty, forme fruste keratoconus, corneal topography, irregular astigmatismKymionis GKontadakis GGrentzelos MPetrelli MDove Medical Pressarticlecorneal crosslinkingphotorefractive keratoplastyforme fruste keratoconuscorneal topographyirregular astigmatismOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2403-2410 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	corneal crosslinking photorefractive keratoplasty forme fruste keratoconus corneal topography irregular astigmatism Ophthalmology RE1-994
spellingShingle	corneal crosslinking photorefractive keratoplasty forme fruste keratoconus corneal topography irregular astigmatism Ophthalmology RE1-994 Kymionis G Kontadakis G Grentzelos M Petrelli M Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects
description	George Kymionis,1 George Kontadakis,1,2 Michael Grentzelos,1 Myrsini Petrelli1 1Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland; 2Laboratory of Vision and Optics, University of Crete, Heraklion, GreeceCorrespondence: George KontadakisLaboratory of Vision and Optics, University of Crete, Heraklion, GreeceEmail kontadas@yahoo.comPurpose: To present the long-term outcomes of photorefractive keratectomy (PRK) combined with accelerated corneal cross-linking (CXL) for refractive error correction in a series of keratoconus suspects.Setting: University practice.Design: Retrospective case series.Methods: A series of patients with topographic findings suspicious for keratoconus underwent simultaneous PRK and prophylactic accelerated CXL (5 minutes with intensity of 18 mW/cm2) for the correction of their refractive error. The results were recorded for more than 4 years postoperatively.Results: Ten eyes of 5 patients were included. Mean follow-up was 58.2 months (range from 54 to 62 months). Mean age at presentation was 25 years (range from 22 to 32 years). Mean spherical equivalent (SE) refraction was − 2.76 (standard deviation [SD] 0.97D, range from − 1.25 to − 4.00 diopters [D]), while mean central corneal thickness was 511μm (SD 13μm, range from 485 to 536 μm). At last, follow-up 9 out of 10 eyes had SE refraction within ± 0.50D and all eyes had SE within ± 1.00D. None of the eyes lost any line of corrected distance visual acuity (CDVA), whereas 1 eye gained one line of CDVA. All eyes demonstrated stability of their results during the follow-up period.Conclusion: Simultaneous PRK followed by prophylactic accelerated CXL (PRK plus) appeared to be a safe and effective option for the correction of the refractive error in this series of keratoconus suspect patients, without compromising corneal stability for up to 5 years postoperatively.Keywords: corneal crosslinking, photorefractive keratoplasty, forme fruste keratoconus, corneal topography, irregular astigmatism
format	article
author	Kymionis G Kontadakis G Grentzelos M Petrelli M
author_facet	Kymionis G Kontadakis G Grentzelos M Petrelli M
author_sort	Kymionis G
title	Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects
title_short	Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects
title_full	Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects
title_fullStr	Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects
title_full_unstemmed	Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects
title_sort	long-term follow-up of combined photorefractive keratectomy and corneal crosslinking in keratoconus suspects
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a830c44df4734b019968bae913d82e5a
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Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects

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