A neuronal network of mitochondrial dynamics regulates metastasis

Mitochondria have a controversial role in cancer. Here, the authors demonstrate the reprogramming of a neuronal network of mitochondrial trafficking in tumor cells, and identify Syntaphilin as a key protein that suppresses organelle dynamics thereby blocking chemotaxis and metastasis in mice.

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Autores principales:	M. Cecilia Caino, Jae Ho Seo, Angeline Aguinaldo, Eric Wait, Kelly G. Bryant, Andrew V. Kossenkov, James E. Hayden, Valentina Vaira, Annamaria Morotti, Stefano Ferrero, Silvano Bosari, Dmitry I. Gabrilovich, Lucia R. Languino, Andrew R. Cohen, Dario C. Altieri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a83307e942fa4962afc59efab303f2dc
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spelling	oai:doaj.org-article:a83307e942fa4962afc59efab303f2dc2021-12-02T14:39:28ZA neuronal network of mitochondrial dynamics regulates metastasis10.1038/ncomms137302041-1723https://doaj.org/article/a83307e942fa4962afc59efab303f2dc2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13730https://doaj.org/toc/2041-1723Mitochondria have a controversial role in cancer. Here, the authors demonstrate the reprogramming of a neuronal network of mitochondrial trafficking in tumor cells, and identify Syntaphilin as a key protein that suppresses organelle dynamics thereby blocking chemotaxis and metastasis in mice.M. Cecilia CainoJae Ho SeoAngeline AguinaldoEric WaitKelly G. BryantAndrew V. KossenkovJames E. HaydenValentina VairaAnnamaria MorottiStefano FerreroSilvano BosariDmitry I. GabrilovichLucia R. LanguinoAndrew R. CohenDario C. AltieriNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Cecilia Caino Jae Ho Seo Angeline Aguinaldo Eric Wait Kelly G. Bryant Andrew V. Kossenkov James E. Hayden Valentina Vaira Annamaria Morotti Stefano Ferrero Silvano Bosari Dmitry I. Gabrilovich Lucia R. Languino Andrew R. Cohen Dario C. Altieri A neuronal network of mitochondrial dynamics regulates metastasis
description	Mitochondria have a controversial role in cancer. Here, the authors demonstrate the reprogramming of a neuronal network of mitochondrial trafficking in tumor cells, and identify Syntaphilin as a key protein that suppresses organelle dynamics thereby blocking chemotaxis and metastasis in mice.
format	article
author	M. Cecilia Caino Jae Ho Seo Angeline Aguinaldo Eric Wait Kelly G. Bryant Andrew V. Kossenkov James E. Hayden Valentina Vaira Annamaria Morotti Stefano Ferrero Silvano Bosari Dmitry I. Gabrilovich Lucia R. Languino Andrew R. Cohen Dario C. Altieri
author_facet	M. Cecilia Caino Jae Ho Seo Angeline Aguinaldo Eric Wait Kelly G. Bryant Andrew V. Kossenkov James E. Hayden Valentina Vaira Annamaria Morotti Stefano Ferrero Silvano Bosari Dmitry I. Gabrilovich Lucia R. Languino Andrew R. Cohen Dario C. Altieri
author_sort	M. Cecilia Caino
title	A neuronal network of mitochondrial dynamics regulates metastasis
title_short	A neuronal network of mitochondrial dynamics regulates metastasis
title_full	A neuronal network of mitochondrial dynamics regulates metastasis
title_fullStr	A neuronal network of mitochondrial dynamics regulates metastasis
title_full_unstemmed	A neuronal network of mitochondrial dynamics regulates metastasis
title_sort	neuronal network of mitochondrial dynamics regulates metastasis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a83307e942fa4962afc59efab303f2dc
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A neuronal network of mitochondrial dynamics regulates metastasis

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