Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report
A 71-year-old female patient with B-cell depletion due to treatment with an anti-CD20 monoclonal antibody was admitted for worsening COVID-19. Overall, she had persistent viral shedding, worsening respiratory failure, and progressive pneumonia that did not improve despite dexamethasone and antibioti...
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Elsevier
2021
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oai:doaj.org-article:a834fbe74cfc422ea3aa8142f10c845b2021-12-04T04:33:57ZSuccessful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report2213-007110.1016/j.rmcr.2021.101560https://doaj.org/article/a834fbe74cfc422ea3aa8142f10c845b2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213007121002227https://doaj.org/toc/2213-0071A 71-year-old female patient with B-cell depletion due to treatment with an anti-CD20 monoclonal antibody was admitted for worsening COVID-19. Overall, she had persistent viral shedding, worsening respiratory failure, and progressive pneumonia that did not improve despite dexamethasone and antibiotic therapy. After administration of bamlanivimab, a monoclonal antibody with high affinity for the receptor-binding domain of the SARS-CoV-2 spike protein, inflammatory markers rapidly decreased, SARS-CoV2 RT-PCR became negative, and the patient improved clinically and radiologically. In conclusion, we demonstrated successful treatment of prolonged COVID-19 in a patient with severe B-cell aplasia with a virus-neutralizing monoclonal antibody.Ayham DaherTobias MüllerJens SpiesshoeferMichael DreherJens PanseElsevierarticleCOVID-19ImmunodeficiencyB-Cell aplasiaMonoclonal antibodiesDiseases of the respiratory systemRC705-779ENRespiratory Medicine Case Reports, Vol 34, Iss , Pp 101560- (2021) |
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DOAJ |
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EN |
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COVID-19 Immunodeficiency B-Cell aplasia Monoclonal antibodies Diseases of the respiratory system RC705-779 |
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COVID-19 Immunodeficiency B-Cell aplasia Monoclonal antibodies Diseases of the respiratory system RC705-779 Ayham Daher Tobias Müller Jens Spiesshoefer Michael Dreher Jens Panse Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report |
| description |
A 71-year-old female patient with B-cell depletion due to treatment with an anti-CD20 monoclonal antibody was admitted for worsening COVID-19. Overall, she had persistent viral shedding, worsening respiratory failure, and progressive pneumonia that did not improve despite dexamethasone and antibiotic therapy. After administration of bamlanivimab, a monoclonal antibody with high affinity for the receptor-binding domain of the SARS-CoV-2 spike protein, inflammatory markers rapidly decreased, SARS-CoV2 RT-PCR became negative, and the patient improved clinically and radiologically. In conclusion, we demonstrated successful treatment of prolonged COVID-19 in a patient with severe B-cell aplasia with a virus-neutralizing monoclonal antibody. |
| format |
article |
| author |
Ayham Daher Tobias Müller Jens Spiesshoefer Michael Dreher Jens Panse |
| author_facet |
Ayham Daher Tobias Müller Jens Spiesshoefer Michael Dreher Jens Panse |
| author_sort |
Ayham Daher |
| title |
Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report |
| title_short |
Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report |
| title_full |
Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report |
| title_fullStr |
Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report |
| title_full_unstemmed |
Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report |
| title_sort |
successful treatment of prolonged covid-19 with bamlanivimab in a patient with severe b-cell aplasia due to treatment with an anti-cd20 monoclonal antibody: a case report |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/a834fbe74cfc422ea3aa8142f10c845b |
| work_keys_str_mv |
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1718372986829930496 |