Astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers
Gout is a form of arthritis caused by hyperuricemia that can significantly affect a patient's quality of life. Here, we investigated the therapeutic effects of astaxanthin, a carotenoid with strong anti-inflammatory and antioxidant properties, on gout. The results of animal experiments showed t...
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2021
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oai:doaj.org-article:a8388610314542dda5c8f33c0f15c2962021-11-04T04:27:41ZAstaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers1756-464610.1016/j.jff.2021.104823https://doaj.org/article/a8388610314542dda5c8f33c0f15c2962021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621004722https://doaj.org/toc/1756-4646Gout is a form of arthritis caused by hyperuricemia that can significantly affect a patient's quality of life. Here, we investigated the therapeutic effects of astaxanthin, a carotenoid with strong anti-inflammatory and antioxidant properties, on gout. The results of animal experiments showed that in terms of animal serological indicators, astaxanthin has the same effect as colchicine in treating gouty arthritis. The outcomes of clinical trials showed that the astaxanthin at 8 mg/d combined with celecoxib at 100 mg/d worked better than celecoxib at 200 mg/d according to ESR and UA, and according to CRP, the effect was comparable. The molecular mechanisms underlying the therapeutic effects of astaxanthin included inhibition of COX-2 and anti-inflammation and anti-oxidation. Collectively, astaxanthin ameliorated gout in rats’ model of gouty arthritis and clinical trials suggesting that it has potential as a dietary supplement to assist in the treatment of gouty arthritis.Lin ZhangHao ChenKaiyue DingShiyong HeGuangxing LiJialin QuYanling QiaoLiu ZhangXue SuiChao FanJin WenWenzhong WuZhengnan GaoDong ShangElsevierarticleAstaxanthinGouty arthritisCyclooxygenase2Randomized controlled trialNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104823- (2021) |
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Astaxanthin Gouty arthritis Cyclooxygenase2 Randomized controlled trial Nutrition. Foods and food supply TX341-641 |
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Astaxanthin Gouty arthritis Cyclooxygenase2 Randomized controlled trial Nutrition. Foods and food supply TX341-641 Lin Zhang Hao Chen Kaiyue Ding Shiyong He Guangxing Li Jialin Qu Yanling Qiao Liu Zhang Xue Sui Chao Fan Jin Wen Wenzhong Wu Zhengnan Gao Dong Shang Astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers |
| description |
Gout is a form of arthritis caused by hyperuricemia that can significantly affect a patient's quality of life. Here, we investigated the therapeutic effects of astaxanthin, a carotenoid with strong anti-inflammatory and antioxidant properties, on gout. The results of animal experiments showed that in terms of animal serological indicators, astaxanthin has the same effect as colchicine in treating gouty arthritis. The outcomes of clinical trials showed that the astaxanthin at 8 mg/d combined with celecoxib at 100 mg/d worked better than celecoxib at 200 mg/d according to ESR and UA, and according to CRP, the effect was comparable. The molecular mechanisms underlying the therapeutic effects of astaxanthin included inhibition of COX-2 and anti-inflammation and anti-oxidation. Collectively, astaxanthin ameliorated gout in rats’ model of gouty arthritis and clinical trials suggesting that it has potential as a dietary supplement to assist in the treatment of gouty arthritis. |
| format |
article |
| author |
Lin Zhang Hao Chen Kaiyue Ding Shiyong He Guangxing Li Jialin Qu Yanling Qiao Liu Zhang Xue Sui Chao Fan Jin Wen Wenzhong Wu Zhengnan Gao Dong Shang |
| author_facet |
Lin Zhang Hao Chen Kaiyue Ding Shiyong He Guangxing Li Jialin Qu Yanling Qiao Liu Zhang Xue Sui Chao Fan Jin Wen Wenzhong Wu Zhengnan Gao Dong Shang |
| author_sort |
Lin Zhang |
| title |
Astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers |
| title_short |
Astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers |
| title_full |
Astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers |
| title_fullStr |
Astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers |
| title_full_unstemmed |
Astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers |
| title_sort |
astaxanthin intake alleviates gouty arthritis in patients and rats by modulating the levels of various inflammatory markers |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/a8388610314542dda5c8f33c0f15c296 |
| work_keys_str_mv |
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