The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients

Abstract Nonmotor symptoms (NMSs) cause major burden in patients with Parkinson’s disease (PD). Previous NMSs progression studies mostly focused on the prevalence. We conducted a longitudinal study to identify the progression pattern by the severity. PD patients recruited from the outpatient clinics...

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Autores principales:	Yi-Chieh Chen, Rou-Shayn Chen, Yi-Hsin Weng, Ying-Zu Huang, Chiung Chu Chen, June Hung, Yi-Ying Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a83974dd6d764def83552558164d2688
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spelling	oai:doaj.org-article:a83974dd6d764def83552558164d26882021-12-02T17:03:50ZThe severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients10.1038/s41598-021-94255-92045-2322https://doaj.org/article/a83974dd6d764def83552558164d26882021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94255-9https://doaj.org/toc/2045-2322Abstract Nonmotor symptoms (NMSs) cause major burden in patients with Parkinson’s disease (PD). Previous NMSs progression studies mostly focused on the prevalence. We conducted a longitudinal study to identify the progression pattern by the severity. PD patients recruited from the outpatient clinics of a tertiary medical center were evaluated by the Unified Parkinson's Disease Rating Scale and Non-Motor Symptoms Scale (NMSS). A retrospective study with three-step analysis was performed. Step 1, the NMSs severity was compared among patients stratified by disease duration every 2 years up to 10 years. Step 2, patients with repeated tests in 2 years were categorized into 4 groups by the diseased duration of every 5 years. Step 3, the NMSS score changes in 6 years follow-up were determined, and the dosage of anti-PD drugs was compared to the NMSs severity changes. 676 patients completed the step 1 analysis, which showed a trend of NMSs worsening but not significant until the disease duration longer than 4–6 years. Furthermore, the severity did not change between repeated evaluations in 2 years in all patients. The progression became apparent after 6 years. Individual symptoms had different progression patterns and the increment of medications was independent to NMSs evolution. We demonstrated the NMSs severity progression in Taiwanese PD patients and the independence of the medications and NMSs progression.Yi-Chieh ChenRou-Shayn ChenYi-Hsin WengYing-Zu HuangChiung Chu ChenJune HungYi-Ying LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Chieh Chen Rou-Shayn Chen Yi-Hsin Weng Ying-Zu Huang Chiung Chu Chen June Hung Yi-Ying Lin The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients
description	Abstract Nonmotor symptoms (NMSs) cause major burden in patients with Parkinson’s disease (PD). Previous NMSs progression studies mostly focused on the prevalence. We conducted a longitudinal study to identify the progression pattern by the severity. PD patients recruited from the outpatient clinics of a tertiary medical center were evaluated by the Unified Parkinson's Disease Rating Scale and Non-Motor Symptoms Scale (NMSS). A retrospective study with three-step analysis was performed. Step 1, the NMSs severity was compared among patients stratified by disease duration every 2 years up to 10 years. Step 2, patients with repeated tests in 2 years were categorized into 4 groups by the diseased duration of every 5 years. Step 3, the NMSS score changes in 6 years follow-up were determined, and the dosage of anti-PD drugs was compared to the NMSs severity changes. 676 patients completed the step 1 analysis, which showed a trend of NMSs worsening but not significant until the disease duration longer than 4–6 years. Furthermore, the severity did not change between repeated evaluations in 2 years in all patients. The progression became apparent after 6 years. Individual symptoms had different progression patterns and the increment of medications was independent to NMSs evolution. We demonstrated the NMSs severity progression in Taiwanese PD patients and the independence of the medications and NMSs progression.
format	article
author	Yi-Chieh Chen Rou-Shayn Chen Yi-Hsin Weng Ying-Zu Huang Chiung Chu Chen June Hung Yi-Ying Lin
author_facet	Yi-Chieh Chen Rou-Shayn Chen Yi-Hsin Weng Ying-Zu Huang Chiung Chu Chen June Hung Yi-Ying Lin
author_sort	Yi-Chieh Chen
title	The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients
title_short	The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients
title_full	The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients
title_fullStr	The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients
title_full_unstemmed	The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients
title_sort	severity progression of non-motor symptoms in parkinson’s disease: a 6-year longitudinal study in taiwanese patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a83974dd6d764def83552558164d2688
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The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients

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