Maternal Thyroid Disease and the Risk of Childhood Cancer in the Offspring

Maternal thyroid disease, especially hypothyroidism, affects pregnancy and its outcome. In-utero exposure to autoimmune thyroid disease has been reported to associate with childhood ALL in the offspring. We evaluated the risk of childhood cancer in the offspring following exposure to maternal thyroi...

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Autores principales:	Laura K. Seppälä, Laura-Maria Madanat-Harjuoja, Maarit K. Leinonen, Mitja Lääperi, Kim Vettenranta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	maternal thyroid disease thyroid hormone childhood cancer adolescent cancer cancer risk case-control Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a83b7ed4067147e5bd828f9ab574056a
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spelling	oai:doaj.org-article:a83b7ed4067147e5bd828f9ab574056a2021-11-11T15:30:33ZMaternal Thyroid Disease and the Risk of Childhood Cancer in the Offspring10.3390/cancers132154092072-6694https://doaj.org/article/a83b7ed4067147e5bd828f9ab574056a2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5409https://doaj.org/toc/2072-6694Maternal thyroid disease, especially hypothyroidism, affects pregnancy and its outcome. In-utero exposure to autoimmune thyroid disease has been reported to associate with childhood ALL in the offspring. We evaluated the risk of childhood cancer in the offspring following exposure to maternal thyroid disease in a case-control setting using registry data. All patients with their first cancer diagnosis below the age of 20 years were identified from the Finnish Cancer Registry (<i>n</i> = 2037) and matched for sex and birth year at a 1:5 ratio to population controls identified from the Medical Birth Registry (<i>n</i> = 10,185). We collected national information on maternal thyroid disease from the Medical Birth Registry, Care Register for Health Care, Register for Reimbursed Drug Purchases and Register of Special Reimbursements. We used conditional logistic regression to analyze childhood cancer risk in the offspring. The adjusted OR for any childhood cancer was 1.41 (95%, CI 1.00–2.00) comparing the offspring of mothers with hypothyroidism and those with normal thyroid function. The risk of lymphomas was increased (adjusted OR for maternal hypothyroidism 3.66, 95%, CI 1.29–10.38). The results remained stable when mothers with cancer history were excluded from the analyses. Maternal hypothyroidism appears to be associated with an increased risk for childhood lymphoma in the offspring. The association exists even after excluding possible familial cancers.Laura K. SeppäläLaura-Maria Madanat-HarjuojaMaarit K. LeinonenMitja LääperiKim VettenrantaMDPI AGarticlematernal thyroid diseasethyroid hormonechildhood canceradolescent cancercancer riskcase-controlNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5409, p 5409 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	maternal thyroid disease thyroid hormone childhood cancer adolescent cancer cancer risk case-control Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	maternal thyroid disease thyroid hormone childhood cancer adolescent cancer cancer risk case-control Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Laura K. Seppälä Laura-Maria Madanat-Harjuoja Maarit K. Leinonen Mitja Lääperi Kim Vettenranta Maternal Thyroid Disease and the Risk of Childhood Cancer in the Offspring
description	Maternal thyroid disease, especially hypothyroidism, affects pregnancy and its outcome. In-utero exposure to autoimmune thyroid disease has been reported to associate with childhood ALL in the offspring. We evaluated the risk of childhood cancer in the offspring following exposure to maternal thyroid disease in a case-control setting using registry data. All patients with their first cancer diagnosis below the age of 20 years were identified from the Finnish Cancer Registry (<i>n</i> = 2037) and matched for sex and birth year at a 1:5 ratio to population controls identified from the Medical Birth Registry (<i>n</i> = 10,185). We collected national information on maternal thyroid disease from the Medical Birth Registry, Care Register for Health Care, Register for Reimbursed Drug Purchases and Register of Special Reimbursements. We used conditional logistic regression to analyze childhood cancer risk in the offspring. The adjusted OR for any childhood cancer was 1.41 (95%, CI 1.00–2.00) comparing the offspring of mothers with hypothyroidism and those with normal thyroid function. The risk of lymphomas was increased (adjusted OR for maternal hypothyroidism 3.66, 95%, CI 1.29–10.38). The results remained stable when mothers with cancer history were excluded from the analyses. Maternal hypothyroidism appears to be associated with an increased risk for childhood lymphoma in the offspring. The association exists even after excluding possible familial cancers.
format	article
author	Laura K. Seppälä Laura-Maria Madanat-Harjuoja Maarit K. Leinonen Mitja Lääperi Kim Vettenranta
author_facet	Laura K. Seppälä Laura-Maria Madanat-Harjuoja Maarit K. Leinonen Mitja Lääperi Kim Vettenranta
author_sort	Laura K. Seppälä
title	Maternal Thyroid Disease and the Risk of Childhood Cancer in the Offspring
title_short	Maternal Thyroid Disease and the Risk of Childhood Cancer in the Offspring
title_full	Maternal Thyroid Disease and the Risk of Childhood Cancer in the Offspring
title_fullStr	Maternal Thyroid Disease and the Risk of Childhood Cancer in the Offspring
title_full_unstemmed	Maternal Thyroid Disease and the Risk of Childhood Cancer in the Offspring
title_sort	maternal thyroid disease and the risk of childhood cancer in the offspring
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a83b7ed4067147e5bd828f9ab574056a
work_keys_str_mv	AT laurakseppala maternalthyroiddiseaseandtheriskofchildhoodcancerintheoffspring AT lauramariamadanatharjuoja maternalthyroiddiseaseandtheriskofchildhoodcancerintheoffspring AT maaritkleinonen maternalthyroiddiseaseandtheriskofchildhoodcancerintheoffspring AT mitjalaaperi maternalthyroiddiseaseandtheriskofchildhoodcancerintheoffspring AT kimvettenranta maternalthyroiddiseaseandtheriskofchildhoodcancerintheoffspring
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Maternal Thyroid Disease and the Risk of Childhood Cancer in the Offspring

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