Power-laws and the use of pluripotent stem cell lines.

It is widely accepted that the (now reversed) Bush administration's decision to restrict federal funding for human embryonic stem cell (hESC) research to a few "eligible" hESC lines is responsible for the sustained preferential use of a small subset of hESC lines (principally the H1 a...

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Autores principales:	Bernhard M Schuldt, Anke Guhr, Michael Lenz, Sabine Kobold, Ben D MacArthur, Andreas Schuppert, Peter Löser, Franz-Josef Müller
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a83bdf8b279d4f4dbdae3e1ec0822651
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spelling	oai:doaj.org-article:a83bdf8b279d4f4dbdae3e1ec08226512021-11-18T08:02:56ZPower-laws and the use of pluripotent stem cell lines.1932-620310.1371/journal.pone.0052068https://doaj.org/article/a83bdf8b279d4f4dbdae3e1ec08226512013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300961/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203It is widely accepted that the (now reversed) Bush administration's decision to restrict federal funding for human embryonic stem cell (hESC) research to a few "eligible" hESC lines is responsible for the sustained preferential use of a small subset of hESC lines (principally the H1 and H9 lines) in basic and preclinical research. Yet, international hESC usage patterns, in both permissive and restrictive political environments, do not correlate with a specific type of stem cell policy. Here we conducted a descriptive analysis of hESC line usage and compared the ability of policy-driven processes and collaborative processes inherent to biomedical research to recapitulate global hESC usage patterns. We find that current global hESC usage can be modelled as a cumulative advantage process, independent of restrictive or permissive policy influence, suggesting a primarily innovation-driven (rather than policy-driven) mechanism underlying human pluripotent stem cell usage in preclinical research.Bernhard M SchuldtAnke GuhrMichael LenzSabine KoboldBen D MacArthurAndreas SchuppertPeter LöserFranz-Josef MüllerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e52068 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bernhard M Schuldt Anke Guhr Michael Lenz Sabine Kobold Ben D MacArthur Andreas Schuppert Peter Löser Franz-Josef Müller Power-laws and the use of pluripotent stem cell lines.
description	It is widely accepted that the (now reversed) Bush administration's decision to restrict federal funding for human embryonic stem cell (hESC) research to a few "eligible" hESC lines is responsible for the sustained preferential use of a small subset of hESC lines (principally the H1 and H9 lines) in basic and preclinical research. Yet, international hESC usage patterns, in both permissive and restrictive political environments, do not correlate with a specific type of stem cell policy. Here we conducted a descriptive analysis of hESC line usage and compared the ability of policy-driven processes and collaborative processes inherent to biomedical research to recapitulate global hESC usage patterns. We find that current global hESC usage can be modelled as a cumulative advantage process, independent of restrictive or permissive policy influence, suggesting a primarily innovation-driven (rather than policy-driven) mechanism underlying human pluripotent stem cell usage in preclinical research.
format	article
author	Bernhard M Schuldt Anke Guhr Michael Lenz Sabine Kobold Ben D MacArthur Andreas Schuppert Peter Löser Franz-Josef Müller
author_facet	Bernhard M Schuldt Anke Guhr Michael Lenz Sabine Kobold Ben D MacArthur Andreas Schuppert Peter Löser Franz-Josef Müller
author_sort	Bernhard M Schuldt
title	Power-laws and the use of pluripotent stem cell lines.
title_short	Power-laws and the use of pluripotent stem cell lines.
title_full	Power-laws and the use of pluripotent stem cell lines.
title_fullStr	Power-laws and the use of pluripotent stem cell lines.
title_full_unstemmed	Power-laws and the use of pluripotent stem cell lines.
title_sort	power-laws and the use of pluripotent stem cell lines.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a83bdf8b279d4f4dbdae3e1ec0822651
work_keys_str_mv	AT bernhardmschuldt powerlawsandtheuseofpluripotentstemcelllines AT ankeguhr powerlawsandtheuseofpluripotentstemcelllines AT michaellenz powerlawsandtheuseofpluripotentstemcelllines AT sabinekobold powerlawsandtheuseofpluripotentstemcelllines AT bendmacarthur powerlawsandtheuseofpluripotentstemcelllines AT andreasschuppert powerlawsandtheuseofpluripotentstemcelllines AT peterloser powerlawsandtheuseofpluripotentstemcelllines AT franzjosefmuller powerlawsandtheuseofpluripotentstemcelllines
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Power-laws and the use of pluripotent stem cell lines.

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