$Use of loteprednol for routine prophylaxis after photorefractive keratectomy$
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Use of loteprednol for routine prophylaxis after photorefractive keratectomy

Mark D Mifflin1, Lisa L Leishman1, Steven M Christiansen1, Shameema Sikder2, Maylon Hsu1, Majid Moshirfar11Department of Ophthalmology, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, 2Wilmer Eye Institute, Johns Hopkins Hospital, Johns Hopkins University, Baltimo...

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Autores principales:	Moshirfar M, Hsu M, Sikder S, Christiansen SM, Mifflin MD, Leishman LL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a83f78ea50544c9fb98146d6c4e1f76a
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spelling	oai:doaj.org-article:a83f78ea50544c9fb98146d6c4e1f76a2021-12-02T02:09:19ZUse of loteprednol for routine prophylaxis after photorefractive keratectomy1177-54671177-5483https://doaj.org/article/a83f78ea50544c9fb98146d6c4e1f76a2012-05-01T00:00:00Zhttp://www.dovepress.com/use-of-loteprednol-for-routine-prophylaxis-after-photorefractive-kerat-a9786https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Mark D Mifflin1, Lisa L Leishman1, Steven M Christiansen1, Shameema Sikder2, Maylon Hsu1, Majid Moshirfar11Department of Ophthalmology, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, 2Wilmer Eye Institute, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, USABackground: The purpose of this work is to report our experience using loteprednol 0.5% for routine prophylaxis after photorefractive keratectomy in an academic refractive surgery center.Materials and methods: Photorefractive keratectomy was performed on 579 eyes from 316 patients in this retrospective chart review of patients treated postoperatively with either fluorometholone 0.1% (273 eyes) or loteprednol 0.5% (306 eyes). Primary outcome measures at 6 months included uncorrected distance visual acuity, corrected distance visual acuity, and manifest refraction spherical equivalent. Secondary outcome measures were incidence of corneal haze and increased intraocular pressure.Results: There were no statistically significant differences in preoperative characteristics between the two groups when comparing age, sex, best-corrected visual acuity, spherical equivalent, or keratometry. Both groups achieved excellent visual outcomes, with a mean uncorrected distance visual acuity (logMAR) of 0.004 &plusmn; 1.4 in the fluorometholone group and &ndash;0.028 &plusmn; 1.1 in the loteprednol group (P = 0.013) at 6 months. Postoperative corneal haze and increased intraocular pressure were uncommon and not statistically different between the groups.Conclusion: Loteprednol 0.5% performed similarly to fluorometholone 0.1% when used for prophylaxis following photorefractive keratectomy. The incidence of haze and increased intraocular pressure were similar between the two groups.Keywords: loteprednol, fluorometholone, photorefractive keratectomyMoshirfar MHsu MSikder SChristiansen SMMifflin MDLeishman LLDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 653-659 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Moshirfar M Hsu M Sikder S Christiansen SM Mifflin MD Leishman LL Use of loteprednol for routine prophylaxis after photorefractive keratectomy
description	Mark D Mifflin1, Lisa L Leishman1, Steven M Christiansen1, Shameema Sikder2, Maylon Hsu1, Majid Moshirfar11Department of Ophthalmology, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, 2Wilmer Eye Institute, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, USABackground: The purpose of this work is to report our experience using loteprednol 0.5% for routine prophylaxis after photorefractive keratectomy in an academic refractive surgery center.Materials and methods: Photorefractive keratectomy was performed on 579 eyes from 316 patients in this retrospective chart review of patients treated postoperatively with either fluorometholone 0.1% (273 eyes) or loteprednol 0.5% (306 eyes). Primary outcome measures at 6 months included uncorrected distance visual acuity, corrected distance visual acuity, and manifest refraction spherical equivalent. Secondary outcome measures were incidence of corneal haze and increased intraocular pressure.Results: There were no statistically significant differences in preoperative characteristics between the two groups when comparing age, sex, best-corrected visual acuity, spherical equivalent, or keratometry. Both groups achieved excellent visual outcomes, with a mean uncorrected distance visual acuity (logMAR) of 0.004 &plusmn; 1.4 in the fluorometholone group and &ndash;0.028 &plusmn; 1.1 in the loteprednol group (P = 0.013) at 6 months. Postoperative corneal haze and increased intraocular pressure were uncommon and not statistically different between the groups.Conclusion: Loteprednol 0.5% performed similarly to fluorometholone 0.1% when used for prophylaxis following photorefractive keratectomy. The incidence of haze and increased intraocular pressure were similar between the two groups.Keywords: loteprednol, fluorometholone, photorefractive keratectomy
format	article
author	Moshirfar M Hsu M Sikder S Christiansen SM Mifflin MD Leishman LL
author_facet	Moshirfar M Hsu M Sikder S Christiansen SM Mifflin MD Leishman LL
author_sort	Moshirfar M
title	Use of loteprednol for routine prophylaxis after photorefractive keratectomy
title_short	Use of loteprednol for routine prophylaxis after photorefractive keratectomy
title_full	Use of loteprednol for routine prophylaxis after photorefractive keratectomy
title_fullStr	Use of loteprednol for routine prophylaxis after photorefractive keratectomy
title_full_unstemmed	Use of loteprednol for routine prophylaxis after photorefractive keratectomy
title_sort	use of loteprednol for routine prophylaxis after photorefractive keratectomy
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/a83f78ea50544c9fb98146d6c4e1f76a
work_keys_str_mv	AT moshirfarm useofloteprednolforroutineprophylaxisafterphotorefractivekeratectomy AT hsum useofloteprednolforroutineprophylaxisafterphotorefractivekeratectomy AT sikders useofloteprednolforroutineprophylaxisafterphotorefractivekeratectomy AT christiansensm useofloteprednolforroutineprophylaxisafterphotorefractivekeratectomy AT mifflinmd useofloteprednolforroutineprophylaxisafterphotorefractivekeratectomy AT leishmanll useofloteprednolforroutineprophylaxisafterphotorefractivekeratectomy
_version_	1718402667902926848

Use of loteprednol for routine prophylaxis after photorefractive keratectomy

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