PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma
Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.
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Nature Portfolio
2019
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oai:doaj.org-article:a841cd70bc974e82bf6c4f6bbe42719f2021-12-02T16:57:52ZPAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma10.1038/s41467-019-11672-12041-1723https://doaj.org/article/a841cd70bc974e82bf6c4f6bbe42719f2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11672-1https://doaj.org/toc/2041-1723Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.Melusine BleuSwann GaulisRui LopesKathleen SprouffskeVerena ApfelSjoerd HolwerdaMarco PregnolatoUmut YildizValentina CordoʹAntonella F. M. DostJudith KnehrWalter CarboneFelix LohmannCharles Y. LinJames E. BradnerAudrey KauffmannLuca TordellaGuglielmo RomaGiorgio G. GalliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Melusine Bleu Swann Gaulis Rui Lopes Kathleen Sprouffske Verena Apfel Sjoerd Holwerda Marco Pregnolato Umut Yildiz Valentina Cordoʹ Antonella F. M. Dost Judith Knehr Walter Carbone Felix Lohmann Charles Y. Lin James E. Bradner Audrey Kauffmann Luca Tordella Guglielmo Roma Giorgio G. Galli PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma |
| description |
Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways. |
| format |
article |
| author |
Melusine Bleu Swann Gaulis Rui Lopes Kathleen Sprouffske Verena Apfel Sjoerd Holwerda Marco Pregnolato Umut Yildiz Valentina Cordoʹ Antonella F. M. Dost Judith Knehr Walter Carbone Felix Lohmann Charles Y. Lin James E. Bradner Audrey Kauffmann Luca Tordella Guglielmo Roma Giorgio G. Galli |
| author_facet |
Melusine Bleu Swann Gaulis Rui Lopes Kathleen Sprouffske Verena Apfel Sjoerd Holwerda Marco Pregnolato Umut Yildiz Valentina Cordoʹ Antonella F. M. Dost Judith Knehr Walter Carbone Felix Lohmann Charles Y. Lin James E. Bradner Audrey Kauffmann Luca Tordella Guglielmo Roma Giorgio G. Galli |
| author_sort |
Melusine Bleu |
| title |
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma |
| title_short |
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma |
| title_full |
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma |
| title_fullStr |
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma |
| title_full_unstemmed |
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma |
| title_sort |
pax8 activates metabolic genes via enhancer elements in renal cell carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/a841cd70bc974e82bf6c4f6bbe42719f |
| work_keys_str_mv |
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1718382463986696192 |