A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia

Abstract Chronic lymphocytic leukemia (CLL) is the most common leukemia in the USA, affecting predominantly older adults. CLL is characterized by low physical fitness, reduced immunity, and increased risk of secondary malignancies and infections. One approach to improving CLL patients’ physical fitn...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Grace MacDonald, Andrea Sitlinger, Michael A. Deal, Erik D. Hanson, Stephanie Ferraro, Carl F. Pieper, J. Brice Weinberg, Danielle M. Brander, David B. Bartlett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a848f2bd84034323aa30f5690e4d9410
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a848f2bd84034323aa30f5690e4d9410
record_format	dspace
spelling	oai:doaj.org-article:a848f2bd84034323aa30f5690e4d94102021-12-05T12:13:24ZA pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia10.1038/s41598-021-02352-62045-2322https://doaj.org/article/a848f2bd84034323aa30f5690e4d94102021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02352-6https://doaj.org/toc/2045-2322Abstract Chronic lymphocytic leukemia (CLL) is the most common leukemia in the USA, affecting predominantly older adults. CLL is characterized by low physical fitness, reduced immunity, and increased risk of secondary malignancies and infections. One approach to improving CLL patients’ physical fitness and immune functions may be participation in a structured exercise program. The aims of this pilot study were to examine physical and immunological changes, and feasibility of a 12-week high-intensity interval training (HIIT) combined with muscle endurance-based resistance training on older adults with treatment naïve CLL. We enrolled eighteen participants with CLL aged 64.9 ± 9.1 years and assigned them to groups depending on distance lived from our fitness center. Ten participants (4 M/6F) completed HIIT and six participants (4 M/2F) completed a non-exercising control group (Controls). HIIT consisted of three 30-min treadmill sessions/week plus two concurrent 30-min strength training sessions/week. Physical and immunological outcomes included aerobic capacity, muscle strength and endurance, and natural killer (NK) cell recognition and killing of tumor cells. We confirmed feasibility if > 70% of HIIT participants completed > 75% of prescribed sessions and prescribed minutes, and if > 80% of high-intensity intervals were at a heart rate corresponding to at least 80% of peak aerobic capacity (VO2peak). Results are presented as Hedge’s G effect sizes (g), with 0.2, 0.5 and 0.8 representing small, medium and large effects, respectively. Following HIIT, leg strength (g = 2.52), chest strength (g = 1.15) and seated row strength (g = 3.07) were 35.4%, 56.1% and 39.5% higher than Controls, respectively, while aerobic capacity was 3.8% lower (g = 0.49) than Controls. Similarly, following HIIT, in vitro NK-cell cytolytic activity against the K562 cell line (g = 1.43), OSU-CLL cell line (g = 0.95), and autologous B-cells (g = 1.30) were 20.3%, 3.0% and 14.6% higher than Controls, respectively. Feasibility was achieved, with HIIT completing 5.0 ± 0.2 sessions/week and 99 ± 3.6% of the prescribed minutes/week at heart rates corresponding to 89 ± 2.8% of VO2peak. We demonstrate that 12-weeks of supervised HIIT combined with muscle endurance-based resistance training is feasible, and that high adherence and compliance are associated with large effects on muscle strength and immune function in older adults with treatment naïve CLL. Trial registration: NCT04950452.Grace MacDonaldAndrea SitlingerMichael A. DealErik D. HansonStephanie FerraroCarl F. PieperJ. Brice WeinbergDanielle M. BranderDavid B. BartlettNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Grace MacDonald Andrea Sitlinger Michael A. Deal Erik D. Hanson Stephanie Ferraro Carl F. Pieper J. Brice Weinberg Danielle M. Brander David B. Bartlett A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia
description	Abstract Chronic lymphocytic leukemia (CLL) is the most common leukemia in the USA, affecting predominantly older adults. CLL is characterized by low physical fitness, reduced immunity, and increased risk of secondary malignancies and infections. One approach to improving CLL patients’ physical fitness and immune functions may be participation in a structured exercise program. The aims of this pilot study were to examine physical and immunological changes, and feasibility of a 12-week high-intensity interval training (HIIT) combined with muscle endurance-based resistance training on older adults with treatment naïve CLL. We enrolled eighteen participants with CLL aged 64.9 ± 9.1 years and assigned them to groups depending on distance lived from our fitness center. Ten participants (4 M/6F) completed HIIT and six participants (4 M/2F) completed a non-exercising control group (Controls). HIIT consisted of three 30-min treadmill sessions/week plus two concurrent 30-min strength training sessions/week. Physical and immunological outcomes included aerobic capacity, muscle strength and endurance, and natural killer (NK) cell recognition and killing of tumor cells. We confirmed feasibility if > 70% of HIIT participants completed > 75% of prescribed sessions and prescribed minutes, and if > 80% of high-intensity intervals were at a heart rate corresponding to at least 80% of peak aerobic capacity (VO2peak). Results are presented as Hedge’s G effect sizes (g), with 0.2, 0.5 and 0.8 representing small, medium and large effects, respectively. Following HIIT, leg strength (g = 2.52), chest strength (g = 1.15) and seated row strength (g = 3.07) were 35.4%, 56.1% and 39.5% higher than Controls, respectively, while aerobic capacity was 3.8% lower (g = 0.49) than Controls. Similarly, following HIIT, in vitro NK-cell cytolytic activity against the K562 cell line (g = 1.43), OSU-CLL cell line (g = 0.95), and autologous B-cells (g = 1.30) were 20.3%, 3.0% and 14.6% higher than Controls, respectively. Feasibility was achieved, with HIIT completing 5.0 ± 0.2 sessions/week and 99 ± 3.6% of the prescribed minutes/week at heart rates corresponding to 89 ± 2.8% of VO2peak. We demonstrate that 12-weeks of supervised HIIT combined with muscle endurance-based resistance training is feasible, and that high adherence and compliance are associated with large effects on muscle strength and immune function in older adults with treatment naïve CLL. Trial registration: NCT04950452.
format	article
author	Grace MacDonald Andrea Sitlinger Michael A. Deal Erik D. Hanson Stephanie Ferraro Carl F. Pieper J. Brice Weinberg Danielle M. Brander David B. Bartlett
author_facet	Grace MacDonald Andrea Sitlinger Michael A. Deal Erik D. Hanson Stephanie Ferraro Carl F. Pieper J. Brice Weinberg Danielle M. Brander David B. Bartlett
author_sort	Grace MacDonald
title	A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia
title_short	A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia
title_full	A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia
title_fullStr	A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia
title_full_unstemmed	A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia
title_sort	pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a848f2bd84034323aa30f5690e4d9410
work_keys_str_mv	AT gracemacdonald apilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT andreasitlinger apilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT michaeladeal apilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT erikdhanson apilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT stephanieferraro apilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT carlfpieper apilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT jbriceweinberg apilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT daniellembrander apilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT davidbbartlett apilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT gracemacdonald pilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT andreasitlinger pilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT michaeladeal pilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT erikdhanson pilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT stephanieferraro pilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT carlfpieper pilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT jbriceweinberg pilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT daniellembrander pilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia AT davidbbartlett pilotstudyofhighintensityintervaltraininginolderadultswithtreatmentnaivechroniclymphocyticleukemia
_version_	1718372149281947648

A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia

Ejemplares similares