Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell activation to avoid targeted elimination, while blocki...

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Autores principales:	Branca I. Pereira, Oliver P. Devine, Milica Vukmanovic-Stejic, Emma S. Chambers, Priya Subramanian, Neil Patel, Alex Virasami, Neil J. Sebire, Veronica Kinsler, Alexis Valdovinos, Claude Jourdan LeSaux, João F. Passos, Antony Antoniou, Malcom H. A. Rustin, Judith Campisi, Arne N. Akbar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a849def66981451db25ae5092d6b7804
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:a849def66981451db25ae5092d6b78042021-12-02T16:57:06ZSenescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition10.1038/s41467-019-10335-52041-1723https://doaj.org/article/a849def66981451db25ae5092d6b78042019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10335-5https://doaj.org/toc/2041-1723Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell activation to avoid targeted elimination, while blocking NKG2A helps promote immunity against senescent cells.Branca I. PereiraOliver P. DevineMilica Vukmanovic-StejicEmma S. ChambersPriya SubramanianNeil PatelAlex VirasamiNeil J. SebireVeronica KinslerAlexis ValdovinosClaude Jourdan LeSauxJoão F. PassosAntony AntoniouMalcom H. A. RustinJudith CampisiArne N. AkbarNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Branca I. Pereira Oliver P. Devine Milica Vukmanovic-Stejic Emma S. Chambers Priya Subramanian Neil Patel Alex Virasami Neil J. Sebire Veronica Kinsler Alexis Valdovinos Claude Jourdan LeSaux João F. Passos Antony Antoniou Malcom H. A. Rustin Judith Campisi Arne N. Akbar Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
description	Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell activation to avoid targeted elimination, while blocking NKG2A helps promote immunity against senescent cells.
format	article
author	Branca I. Pereira Oliver P. Devine Milica Vukmanovic-Stejic Emma S. Chambers Priya Subramanian Neil Patel Alex Virasami Neil J. Sebire Veronica Kinsler Alexis Valdovinos Claude Jourdan LeSaux João F. Passos Antony Antoniou Malcom H. A. Rustin Judith Campisi Arne N. Akbar
author_facet	Branca I. Pereira Oliver P. Devine Milica Vukmanovic-Stejic Emma S. Chambers Priya Subramanian Neil Patel Alex Virasami Neil J. Sebire Veronica Kinsler Alexis Valdovinos Claude Jourdan LeSaux João F. Passos Antony Antoniou Malcom H. A. Rustin Judith Campisi Arne N. Akbar
author_sort	Branca I. Pereira
title	Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
title_short	Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
title_full	Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
title_fullStr	Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
title_full_unstemmed	Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
title_sort	senescent cells evade immune clearance via hla-e-mediated nk and cd8+ t cell inhibition
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a849def66981451db25ae5092d6b7804
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Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

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