Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.

During general anesthesia, both behavioral and autonomic changes are caused by the administration of anesthetics such as propofol. Propofol produces unconsciousness by creating highly structured oscillations in brain circuits. The anesthetic also has autonomic effects due to its actions as a vasodil...

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Autores principales:	Sandya Subramanian, Patrick L Purdon, Riccardo Barbieri, Emery N Brown
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a84a46e3c9324ff497c8451871ddf847
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spelling	oai:doaj.org-article:a84a46e3c9324ff497c8451871ddf8472021-12-02T20:15:05ZQuantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.1932-620310.1371/journal.pone.0254053https://doaj.org/article/a84a46e3c9324ff497c8451871ddf8472021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254053https://doaj.org/toc/1932-6203During general anesthesia, both behavioral and autonomic changes are caused by the administration of anesthetics such as propofol. Propofol produces unconsciousness by creating highly structured oscillations in brain circuits. The anesthetic also has autonomic effects due to its actions as a vasodilator and myocardial depressant. Understanding how autonomic dynamics change in relation to propofol-induced unconsciousness is an important scientific and clinical question since anesthesiologists often infer changes in level of unconsciousness from changes in autonomic dynamics. Therefore, we present a framework combining physiology-based statistical models that have been developed specifically for heart rate variability and electrodermal activity with a robust statistical tool to compare behavioral and multimodal autonomic changes before, during, and after propofol-induced unconsciousness. We tested this framework on physiological data recorded from nine healthy volunteers during computer-controlled administration of propofol. We studied how autonomic dynamics related to behavioral markers of unconsciousness: 1) overall, 2) during the transitions of loss and recovery of consciousness, and 3) before and after anesthesia as a whole. Our results show a strong relationship between behavioral state of consciousness and autonomic dynamics. All of our prediction models showed areas under the curve greater than 0.75 despite the presence of non-monotonic relationships among the variables during the transition periods. Our analysis highlighted the specific roles played by fast versus slow changes, parasympathetic vs sympathetic activity, heart rate variability vs electrodermal activity, and even pulse rate vs pulse amplitude information within electrodermal activity. Further advancement upon this work can quantify the complex and subject-specific relationship between behavioral changes and autonomic dynamics before, during, and after anesthesia. However, this work demonstrates the potential of a multimodal, physiologically-informed, statistical approach to characterize autonomic dynamics.Sandya SubramanianPatrick L PurdonRiccardo BarbieriEmery N BrownPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0254053 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandya Subramanian Patrick L Purdon Riccardo Barbieri Emery N Brown Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.
description	During general anesthesia, both behavioral and autonomic changes are caused by the administration of anesthetics such as propofol. Propofol produces unconsciousness by creating highly structured oscillations in brain circuits. The anesthetic also has autonomic effects due to its actions as a vasodilator and myocardial depressant. Understanding how autonomic dynamics change in relation to propofol-induced unconsciousness is an important scientific and clinical question since anesthesiologists often infer changes in level of unconsciousness from changes in autonomic dynamics. Therefore, we present a framework combining physiology-based statistical models that have been developed specifically for heart rate variability and electrodermal activity with a robust statistical tool to compare behavioral and multimodal autonomic changes before, during, and after propofol-induced unconsciousness. We tested this framework on physiological data recorded from nine healthy volunteers during computer-controlled administration of propofol. We studied how autonomic dynamics related to behavioral markers of unconsciousness: 1) overall, 2) during the transitions of loss and recovery of consciousness, and 3) before and after anesthesia as a whole. Our results show a strong relationship between behavioral state of consciousness and autonomic dynamics. All of our prediction models showed areas under the curve greater than 0.75 despite the presence of non-monotonic relationships among the variables during the transition periods. Our analysis highlighted the specific roles played by fast versus slow changes, parasympathetic vs sympathetic activity, heart rate variability vs electrodermal activity, and even pulse rate vs pulse amplitude information within electrodermal activity. Further advancement upon this work can quantify the complex and subject-specific relationship between behavioral changes and autonomic dynamics before, during, and after anesthesia. However, this work demonstrates the potential of a multimodal, physiologically-informed, statistical approach to characterize autonomic dynamics.
format	article
author	Sandya Subramanian Patrick L Purdon Riccardo Barbieri Emery N Brown
author_facet	Sandya Subramanian Patrick L Purdon Riccardo Barbieri Emery N Brown
author_sort	Sandya Subramanian
title	Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.
title_short	Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.
title_full	Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.
title_fullStr	Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.
title_full_unstemmed	Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.
title_sort	quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a84a46e3c9324ff497c8451871ddf847
work_keys_str_mv	AT sandyasubramanian quantitativeassessmentoftherelationshipbetweenbehavioralandautonomicdynamicsduringpropofolinducedunconsciousness AT patricklpurdon quantitativeassessmentoftherelationshipbetweenbehavioralandautonomicdynamicsduringpropofolinducedunconsciousness AT riccardobarbieri quantitativeassessmentoftherelationshipbetweenbehavioralandautonomicdynamicsduringpropofolinducedunconsciousness AT emerynbrown quantitativeassessmentoftherelationshipbetweenbehavioralandautonomicdynamicsduringpropofolinducedunconsciousness
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Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.

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