The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome

Although polycystic ovary syndrome is the most common cause of female infertility, its etiology remains poorly understood. Here, the authors report a rat model that spontaneously exhibits the clinical heterogeneity of this syndrome and demonstrate that the phenotype is developmentally programmed.

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Autores principales: Camille Bourgneuf, Danielle Bailbé, Antonin Lamazière, Charlotte Dupont, Marthe Moldes, Dominique Farabos, Natacha Roblot, Camille Gauthier, Emmanuelle Mathieu d’Argent, Joelle Cohen-Tannoudji, Danielle Monniaux, Bruno Fève, Jamileh Movassat, Nathalie di Clemente, Chrystèle Racine
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a84b71732825487faccefd48f4c84bb1
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Sumario:Although polycystic ovary syndrome is the most common cause of female infertility, its etiology remains poorly understood. Here, the authors report a rat model that spontaneously exhibits the clinical heterogeneity of this syndrome and demonstrate that the phenotype is developmentally programmed.