The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome

The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome

Although polycystic ovary syndrome is the most common cause of female infertility, its etiology remains poorly understood. Here, the authors report a rat model that spontaneously exhibits the clinical heterogeneity of this syndrome and demonstrate that the phenotype is developmentally programmed.

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Autores principales: Camille Bourgneuf, Danielle Bailbé, Antonin Lamazière, Charlotte Dupont, Marthe Moldes, Dominique Farabos, Natacha Roblot, Camille Gauthier, Emmanuelle Mathieu d’Argent, Joelle Cohen-Tannoudji, Danielle Monniaux, Bruno Fève, Jamileh Movassat, Nathalie di Clemente, Chrystèle Racine
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a84b71732825487faccefd48f4c84bb1
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spelling oai:doaj.org-article:a84b71732825487faccefd48f4c84bb12021-12-02T14:03:50ZThe Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome10.1038/s41467-021-21308-y2041-1723https://doaj.org/article/a84b71732825487faccefd48f4c84bb12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21308-yhttps://doaj.org/toc/2041-1723Although polycystic ovary syndrome is the most common cause of female infertility, its etiology remains poorly understood. Here, the authors report a rat model that spontaneously exhibits the clinical heterogeneity of this syndrome and demonstrate that the phenotype is developmentally programmed.Camille BourgneufDanielle BailbéAntonin LamazièreCharlotte DupontMarthe MoldesDominique FarabosNatacha RoblotCamille GauthierEmmanuelle Mathieu d’ArgentJoelle Cohen-TannoudjiDanielle MonniauxBruno FèveJamileh MovassatNathalie di ClementeChrystèle RacineNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Camille Bourgneuf
Danielle Bailbé
Antonin Lamazière
Charlotte Dupont
Marthe Moldes
Dominique Farabos
Natacha Roblot
Camille Gauthier
Emmanuelle Mathieu d’Argent
Joelle Cohen-Tannoudji
Danielle Monniaux
Bruno Fève
Jamileh Movassat
Nathalie di Clemente
Chrystèle Racine
The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome
description Although polycystic ovary syndrome is the most common cause of female infertility, its etiology remains poorly understood. Here, the authors report a rat model that spontaneously exhibits the clinical heterogeneity of this syndrome and demonstrate that the phenotype is developmentally programmed.
format article
author Camille Bourgneuf
Danielle Bailbé
Antonin Lamazière
Charlotte Dupont
Marthe Moldes
Dominique Farabos
Natacha Roblot
Camille Gauthier
Emmanuelle Mathieu d’Argent
Joelle Cohen-Tannoudji
Danielle Monniaux
Bruno Fève
Jamileh Movassat
Nathalie di Clemente
Chrystèle Racine
author_facet Camille Bourgneuf
Danielle Bailbé
Antonin Lamazière
Charlotte Dupont
Marthe Moldes
Dominique Farabos
Natacha Roblot
Camille Gauthier
Emmanuelle Mathieu d’Argent
Joelle Cohen-Tannoudji
Danielle Monniaux
Bruno Fève
Jamileh Movassat
Nathalie di Clemente
Chrystèle Racine
author_sort Camille Bourgneuf
title The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome
title_short The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome
title_full The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome
title_fullStr The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome
title_full_unstemmed The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome
title_sort goto-kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a84b71732825487faccefd48f4c84bb1
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