Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study

Abstract Background Anaemia has been reported to be associated with cognitive decline and Alzheimer’s disease (AD), but the associations between anaemia and cerebrospinal fluid (CSF) AD biomarkers are still unknown. This study aimed to investigate the associations between anaemia and CSF AD biomarke...

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Autores principales:	Xin-Yu Yang, Xiao-He Hou, Yan-Lin Bi, Hao Hu, Xi-Peng Cao, Lan Tan, Jiu-Long Yang, Jin-Tai Yu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Anaemia Severity Alzheimer’s disease Cerebrospinal fluid Biomarkers Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a84dde9623f14f5cbcc65348fd26624d
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spelling	oai:doaj.org-article:a84dde9623f14f5cbcc65348fd26624d2021-11-21T12:09:30ZAnaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study10.1186/s12883-021-02487-z1471-2377https://doaj.org/article/a84dde9623f14f5cbcc65348fd26624d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12883-021-02487-zhttps://doaj.org/toc/1471-2377Abstract Background Anaemia has been reported to be associated with cognitive decline and Alzheimer’s disease (AD), but the associations between anaemia and cerebrospinal fluid (CSF) AD biomarkers are still unknown. This study aimed to investigate the associations between anaemia and CSF AD biomarkers. Methods Participants were included from the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) study. The associations of anaemia and its severity with CSF AD biomarkers including β-amyloid 1–42 (Aβ42), total tau (t-tau) and phosphorylated tau (p-tau) were analysed by multiple linear regression models. Adjusted for age, gender, educational levels, APOE ε4 alleles, comorbidities (history of coronary heart disease, history of stroke, hypertension, diabetes mellitus, dyslipidaemia) and glomerular filtration rate. Results A total of 646 cognitively normal older adults, consisting of 117 anaemia patients and 529 non-anaemia individuals, were included in this study. Anaemia patients had lower levels of CSF Aβ42 than individuals without anaemia (p = 0.035). Besides, participants with more severe anaemia had lower CSF Aβ42 levels (p = 0.045). No significant association of anaemia with CSF t-tau and p-tau levels was found. Conclusion Cross-sectionally, anaemia was associated with lower CSF Aβ42 levels. These findings consolidated the causal close relationship between anaemia and AD.Xin-Yu YangXiao-He HouYan-Lin BiHao HuXi-Peng CaoLan TanJiu-Long YangJin-Tai YuBMCarticleAnaemiaSeverityAlzheimer’s diseaseCerebrospinal fluidBiomarkersNeurology. Diseases of the nervous systemRC346-429ENBMC Neurology, Vol 21, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anaemia Severity Alzheimer’s disease Cerebrospinal fluid Biomarkers Neurology. Diseases of the nervous system RC346-429
spellingShingle	Anaemia Severity Alzheimer’s disease Cerebrospinal fluid Biomarkers Neurology. Diseases of the nervous system RC346-429 Xin-Yu Yang Xiao-He Hou Yan-Lin Bi Hao Hu Xi-Peng Cao Lan Tan Jiu-Long Yang Jin-Tai Yu Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study
description	Abstract Background Anaemia has been reported to be associated with cognitive decline and Alzheimer’s disease (AD), but the associations between anaemia and cerebrospinal fluid (CSF) AD biomarkers are still unknown. This study aimed to investigate the associations between anaemia and CSF AD biomarkers. Methods Participants were included from the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) study. The associations of anaemia and its severity with CSF AD biomarkers including β-amyloid 1–42 (Aβ42), total tau (t-tau) and phosphorylated tau (p-tau) were analysed by multiple linear regression models. Adjusted for age, gender, educational levels, APOE ε4 alleles, comorbidities (history of coronary heart disease, history of stroke, hypertension, diabetes mellitus, dyslipidaemia) and glomerular filtration rate. Results A total of 646 cognitively normal older adults, consisting of 117 anaemia patients and 529 non-anaemia individuals, were included in this study. Anaemia patients had lower levels of CSF Aβ42 than individuals without anaemia (p = 0.035). Besides, participants with more severe anaemia had lower CSF Aβ42 levels (p = 0.045). No significant association of anaemia with CSF t-tau and p-tau levels was found. Conclusion Cross-sectionally, anaemia was associated with lower CSF Aβ42 levels. These findings consolidated the causal close relationship between anaemia and AD.
format	article
author	Xin-Yu Yang Xiao-He Hou Yan-Lin Bi Hao Hu Xi-Peng Cao Lan Tan Jiu-Long Yang Jin-Tai Yu
author_facet	Xin-Yu Yang Xiao-He Hou Yan-Lin Bi Hao Hu Xi-Peng Cao Lan Tan Jiu-Long Yang Jin-Tai Yu
author_sort	Xin-Yu Yang
title	Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study
title_short	Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study
title_full	Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study
title_fullStr	Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study
title_full_unstemmed	Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study
title_sort	anaemia and cerebrospinal fluid biomarkers of alzheimer’s pathology in cognitively normal elders: the cable study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a84dde9623f14f5cbcc65348fd26624d
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Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study

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