The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

During development, H3K27me3 is reallocated from large domains in preimplantation embryos to mark promoters of developmental genes. Here the authors show that the deubiquitinase Usp9x interacts with, deubiquitinates and stabilizes PRC2 and provide evidence that a Usp9x-PRC2 regulatory axis is critic...

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Autores principales: Trisha A. Macrae, Miguel Ramalho-Santos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a84ff6c13f7f48ca89c8b065a6058632
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spelling oai:doaj.org-article:a84ff6c13f7f48ca89c8b065a60586322021-12-02T14:02:52ZThe deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development10.1038/s41467-021-21910-02041-1723https://doaj.org/article/a84ff6c13f7f48ca89c8b065a60586322021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21910-0https://doaj.org/toc/2041-1723During development, H3K27me3 is reallocated from large domains in preimplantation embryos to mark promoters of developmental genes. Here the authors show that the deubiquitinase Usp9x interacts with, deubiquitinates and stabilizes PRC2 and provide evidence that a Usp9x-PRC2 regulatory axis is critical at peri-implantation.Trisha A. MacraeMiguel Ramalho-SantosNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Trisha A. Macrae
Miguel Ramalho-Santos
The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
description During development, H3K27me3 is reallocated from large domains in preimplantation embryos to mark promoters of developmental genes. Here the authors show that the deubiquitinase Usp9x interacts with, deubiquitinates and stabilizes PRC2 and provide evidence that a Usp9x-PRC2 regulatory axis is critical at peri-implantation.
format article
author Trisha A. Macrae
Miguel Ramalho-Santos
author_facet Trisha A. Macrae
Miguel Ramalho-Santos
author_sort Trisha A. Macrae
title The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
title_short The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
title_full The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
title_fullStr The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
title_full_unstemmed The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
title_sort deubiquitinase usp9x regulates prc2-mediated chromatin reprogramming during mouse development
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a84ff6c13f7f48ca89c8b065a6058632
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AT trishaamacrae deubiquitinaseusp9xregulatesprc2mediatedchromatinreprogrammingduringmousedevelopment
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