Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.

Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found th...

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Autores principales:	Nuria Seguí, Elisabet Guinó, Marta Pineda, Matilde Navarro, Fernando Bellido, Conxi Lázaro, Ignacio Blanco, Victor Moreno, Gabriel Capellá, Laura Valle
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8515c67e76b44bb83aa678677b58009
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spelling	oai:doaj.org-article:a8515c67e76b44bb83aa678677b580092021-11-18T08:34:21ZLonger telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.1932-620310.1371/journal.pone.0086063https://doaj.org/article/a8515c67e76b44bb83aa678677b580092014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498269/?tool=EBIhttps://doaj.org/toc/1932-6203Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found that cancer-affected MMR gene mutation carriers had shorter telomeres and more pronounced shortening of telomere length with age than controls and unaffected MMR gene mutation carriers. Here we evaluate blood telomere length in MMR-proficient hereditary non-polyposis CRC, i.e. familial CRC type X (fCRC-X). A total of 57 cancer-affected and 57 cancer-free individuals from 34 Amsterdam-positive fCRC-X families were analyzed and compared to the data previously published on 144 cancer-affected and 100 cancer-free MMR gene mutation carriers, and 234 controls. Relative telomere length was measured using a monochrome multiplex quantitative PCR method, following strict measures to avoid sources of bias and adjusting by age. Despite the retrospective nature of our study, the results show that longer telomeres associate with cancer risk in fCRC-X, thus identifying different patterns of telomere length according to the status of the MMR system.Nuria SeguíElisabet GuinóMarta PinedaMatilde NavarroFernando BellidoConxi LázaroIgnacio BlancoVictor MorenoGabriel CapelláLaura VallePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e86063 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nuria Seguí Elisabet Guinó Marta Pineda Matilde Navarro Fernando Bellido Conxi Lázaro Ignacio Blanco Victor Moreno Gabriel Capellá Laura Valle Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.
description	Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found that cancer-affected MMR gene mutation carriers had shorter telomeres and more pronounced shortening of telomere length with age than controls and unaffected MMR gene mutation carriers. Here we evaluate blood telomere length in MMR-proficient hereditary non-polyposis CRC, i.e. familial CRC type X (fCRC-X). A total of 57 cancer-affected and 57 cancer-free individuals from 34 Amsterdam-positive fCRC-X families were analyzed and compared to the data previously published on 144 cancer-affected and 100 cancer-free MMR gene mutation carriers, and 234 controls. Relative telomere length was measured using a monochrome multiplex quantitative PCR method, following strict measures to avoid sources of bias and adjusting by age. Despite the retrospective nature of our study, the results show that longer telomeres associate with cancer risk in fCRC-X, thus identifying different patterns of telomere length according to the status of the MMR system.
format	article
author	Nuria Seguí Elisabet Guinó Marta Pineda Matilde Navarro Fernando Bellido Conxi Lázaro Ignacio Blanco Victor Moreno Gabriel Capellá Laura Valle
author_facet	Nuria Seguí Elisabet Guinó Marta Pineda Matilde Navarro Fernando Bellido Conxi Lázaro Ignacio Blanco Victor Moreno Gabriel Capellá Laura Valle
author_sort	Nuria Seguí
title	Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.
title_short	Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.
title_full	Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.
title_fullStr	Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.
title_full_unstemmed	Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.
title_sort	longer telomeres are associated with cancer risk in mmr-proficient hereditary non-polyposis colorectal cancer.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/a8515c67e76b44bb83aa678677b58009
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Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.

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