Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan

Childhood adversity is associated with a host of mental and physical health problems across the lifespan. Individuals who have experienced childhood adversity (e.g., child abuse and neglect, family conflict, poor parent/child relationships, low socioeconomic status or extreme poverty) are at a great...

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Autores principales:	Michelle A. Chen, Angie S. LeRoy, Marzieh Majd, Jonathan Y. Chen, Ryan L. Brown, Lisa M. Christian, Christopher P. Fagundes
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	childhood adversity early life stress immune pathways epigenetic pathways inflammation Psychology BF1-990
Acceso en línea:	https://doaj.org/article/a852572437ed47d88c217f04f40d2fd2
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spelling	oai:doaj.org-article:a852572437ed47d88c217f04f40d2fd22021-12-01T07:57:31ZImmune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan1664-107810.3389/fpsyg.2021.788351https://doaj.org/article/a852572437ed47d88c217f04f40d2fd22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyg.2021.788351/fullhttps://doaj.org/toc/1664-1078Childhood adversity is associated with a host of mental and physical health problems across the lifespan. Individuals who have experienced childhood adversity (e.g., child abuse and neglect, family conflict, poor parent/child relationships, low socioeconomic status or extreme poverty) are at a greater risk for morbidity and premature mortality than those not exposed to childhood adversity. Several mechanisms likely contribute to the relationship between childhood adversity and health across the lifespan (e.g., health behaviors, cardiovascular reactivity). In this paper, we review a large body of research within the field of psychoneuroimmunology, demonstrating the relationship between early life stress and alterations of the immune system. We first review the literature demonstrating that childhood adversity is associated with immune dysregulation across different indices, including proinflammatory cytokine production (and its impact on telomere length), illness and infection susceptibility, latent herpesvirus reactivation, and immune response to a tumor. We then summarize the growing literature on how childhood adversity may alter epigenetic processes. Finally, we propose future directions related to this work that have basic and applied implications.Michelle A. ChenAngie S. LeRoyMarzieh MajdJonathan Y. ChenRyan L. BrownLisa M. ChristianChristopher P. FagundesChristopher P. FagundesChristopher P. FagundesFrontiers Media S.A.articlechildhood adversityearly life stressimmune pathwaysepigenetic pathwaysinflammationPsychologyBF1-990ENFrontiers in Psychology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	childhood adversity early life stress immune pathways epigenetic pathways inflammation Psychology BF1-990
spellingShingle	childhood adversity early life stress immune pathways epigenetic pathways inflammation Psychology BF1-990 Michelle A. Chen Angie S. LeRoy Marzieh Majd Jonathan Y. Chen Ryan L. Brown Lisa M. Christian Christopher P. Fagundes Christopher P. Fagundes Christopher P. Fagundes Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan
description	Childhood adversity is associated with a host of mental and physical health problems across the lifespan. Individuals who have experienced childhood adversity (e.g., child abuse and neglect, family conflict, poor parent/child relationships, low socioeconomic status or extreme poverty) are at a greater risk for morbidity and premature mortality than those not exposed to childhood adversity. Several mechanisms likely contribute to the relationship between childhood adversity and health across the lifespan (e.g., health behaviors, cardiovascular reactivity). In this paper, we review a large body of research within the field of psychoneuroimmunology, demonstrating the relationship between early life stress and alterations of the immune system. We first review the literature demonstrating that childhood adversity is associated with immune dysregulation across different indices, including proinflammatory cytokine production (and its impact on telomere length), illness and infection susceptibility, latent herpesvirus reactivation, and immune response to a tumor. We then summarize the growing literature on how childhood adversity may alter epigenetic processes. Finally, we propose future directions related to this work that have basic and applied implications.
format	article
author	Michelle A. Chen Angie S. LeRoy Marzieh Majd Jonathan Y. Chen Ryan L. Brown Lisa M. Christian Christopher P. Fagundes Christopher P. Fagundes Christopher P. Fagundes
author_facet	Michelle A. Chen Angie S. LeRoy Marzieh Majd Jonathan Y. Chen Ryan L. Brown Lisa M. Christian Christopher P. Fagundes Christopher P. Fagundes Christopher P. Fagundes
author_sort	Michelle A. Chen
title	Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan
title_short	Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan
title_full	Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan
title_fullStr	Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan
title_full_unstemmed	Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan
title_sort	immune and epigenetic pathways linking childhood adversity and health across the lifespan
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a852572437ed47d88c217f04f40d2fd2
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Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan

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