Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping

Genome-scale engineering is generally limited to single methods of alteration such as overexpression, repression or deletion. Here the authors present a tri-functional CRISPR system that can engineer complex synergistic interactions in a genome-wide manner.

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Autores principales:	Jiazhang Lian, Carl Schultz, Mingfeng Cao, Mohammad HamediRad, Huimin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8527807c1b148f7874c1327906d4167
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spelling	oai:doaj.org-article:a8527807c1b148f7874c1327906d41672021-12-02T15:35:32ZMulti-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping10.1038/s41467-019-13621-42041-1723https://doaj.org/article/a8527807c1b148f7874c1327906d41672019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13621-4https://doaj.org/toc/2041-1723Genome-scale engineering is generally limited to single methods of alteration such as overexpression, repression or deletion. Here the authors present a tri-functional CRISPR system that can engineer complex synergistic interactions in a genome-wide manner.Jiazhang LianCarl SchultzMingfeng CaoMohammad HamediRadHuimin ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiazhang Lian Carl Schultz Mingfeng Cao Mohammad HamediRad Huimin Zhao Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
description	Genome-scale engineering is generally limited to single methods of alteration such as overexpression, repression or deletion. Here the authors present a tri-functional CRISPR system that can engineer complex synergistic interactions in a genome-wide manner.
format	article
author	Jiazhang Lian Carl Schultz Mingfeng Cao Mohammad HamediRad Huimin Zhao
author_facet	Jiazhang Lian Carl Schultz Mingfeng Cao Mohammad HamediRad Huimin Zhao
author_sort	Jiazhang Lian
title	Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
title_short	Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
title_full	Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
title_fullStr	Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
title_full_unstemmed	Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
title_sort	multi-functional genome-wide crispr system for high throughput genotype–phenotype mapping
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a8527807c1b148f7874c1327906d4167
work_keys_str_mv	AT jiazhanglian multifunctionalgenomewidecrisprsystemforhighthroughputgenotypephenotypemapping AT carlschultz multifunctionalgenomewidecrisprsystemforhighthroughputgenotypephenotypemapping AT mingfengcao multifunctionalgenomewidecrisprsystemforhighthroughputgenotypephenotypemapping AT mohammadhamedirad multifunctionalgenomewidecrisprsystemforhighthroughputgenotypephenotypemapping AT huiminzhao multifunctionalgenomewidecrisprsystemforhighthroughputgenotypephenotypemapping
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Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping

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