Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
Genome-scale engineering is generally limited to single methods of alteration such as overexpression, repression or deletion. Here the authors present a tri-functional CRISPR system that can engineer complex synergistic interactions in a genome-wide manner.
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Autores principales: | Jiazhang Lian, Carl Schultz, Mingfeng Cao, Mohammad HamediRad, Huimin Zhao |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/a8527807c1b148f7874c1327906d4167 |
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