Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers

Cross-linking mass spectrometry can provide insights into protein structures and interactions but its scope depends on the reactivity of the cross-linker. Here, the authors develop Arg-Arg and Lys-Arg cross-linkers, which provide structural information elusive to the widely used Lys-Lys cross-linker...

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Autores principales:	Alexander X. Jones, Yong Cao, Yu-Liang Tang, Jian-Hua Wang, Yue-He Ding, Hui Tan, Zhen-Lin Chen, Run-Qian Fang, Jili Yin, Rong-Chang Chen, Xing Zhu, Yang She, Niu Huang, Feng Shao, Keqiong Ye, Rui-Xiang Sun, Si-Min He, Xiaoguang Lei, Meng-Qiu Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a855dbbbf40242cb82962d2fa4fbde46
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spelling	oai:doaj.org-article:a855dbbbf40242cb82962d2fa4fbde462021-12-02T16:57:30ZImproving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers10.1038/s41467-019-11917-z2041-1723https://doaj.org/article/a855dbbbf40242cb82962d2fa4fbde462019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11917-zhttps://doaj.org/toc/2041-1723Cross-linking mass spectrometry can provide insights into protein structures and interactions but its scope depends on the reactivity of the cross-linker. Here, the authors develop Arg-Arg and Lys-Arg cross-linkers, which provide structural information elusive to the widely used Lys-Lys cross-linkers.Alexander X. JonesYong CaoYu-Liang TangJian-Hua WangYue-He DingHui TanZhen-Lin ChenRun-Qian FangJili YinRong-Chang ChenXing ZhuYang SheNiu HuangFeng ShaoKeqiong YeRui-Xiang SunSi-Min HeXiaoguang LeiMeng-Qiu DongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander X. Jones Yong Cao Yu-Liang Tang Jian-Hua Wang Yue-He Ding Hui Tan Zhen-Lin Chen Run-Qian Fang Jili Yin Rong-Chang Chen Xing Zhu Yang She Niu Huang Feng Shao Keqiong Ye Rui-Xiang Sun Si-Min He Xiaoguang Lei Meng-Qiu Dong Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
description	Cross-linking mass spectrometry can provide insights into protein structures and interactions but its scope depends on the reactivity of the cross-linker. Here, the authors develop Arg-Arg and Lys-Arg cross-linkers, which provide structural information elusive to the widely used Lys-Lys cross-linkers.
format	article
author	Alexander X. Jones Yong Cao Yu-Liang Tang Jian-Hua Wang Yue-He Ding Hui Tan Zhen-Lin Chen Run-Qian Fang Jili Yin Rong-Chang Chen Xing Zhu Yang She Niu Huang Feng Shao Keqiong Ye Rui-Xiang Sun Si-Min He Xiaoguang Lei Meng-Qiu Dong
author_facet	Alexander X. Jones Yong Cao Yu-Liang Tang Jian-Hua Wang Yue-He Ding Hui Tan Zhen-Lin Chen Run-Qian Fang Jili Yin Rong-Chang Chen Xing Zhu Yang She Niu Huang Feng Shao Keqiong Ye Rui-Xiang Sun Si-Min He Xiaoguang Lei Meng-Qiu Dong
author_sort	Alexander X. Jones
title	Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
title_short	Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
title_full	Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
title_fullStr	Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
title_full_unstemmed	Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
title_sort	improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a855dbbbf40242cb82962d2fa4fbde46
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Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers

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