Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia

Ibrahim Turkoz, Cynthia A Bossie, Bryan Dirks, Carla M CanusoOrtho-McNeil Janssen Scientific Affairs, LLC, Titusville, NJ, USAAbstract: Direct and indirect effects of the new psychotropic paliperidone extended-release (paliperidone ER) tablets on negative symptom improvement in schizophrenia were in...

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Autores principales:	Ibrahim Turkoz, Cynthia A Bossie, Bryan Dirks, Carla M Canuso
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a85737ed2de249969bd1778a236c12c1
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spelling	oai:doaj.org-article:a85737ed2de249969bd1778a236c12c12021-12-02T02:08:56ZDirect and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia1176-63281178-2021https://doaj.org/article/a85737ed2de249969bd1778a236c12c12008-08-01T00:00:00Zhttp://www.dovepress.com/direct-and-indirect-effects-of-paliperidone-extended-release-tablets-o-a2012https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Ibrahim Turkoz, Cynthia A Bossie, Bryan Dirks, Carla M CanusoOrtho-McNeil Janssen Scientific Affairs, LLC, Titusville, NJ, USAAbstract: Direct and indirect effects of the new psychotropic paliperidone extended-release (paliperidone ER) tablets on negative symptom improvement in schizophrenia were investigated using path analysis. A post hoc analysis of pooled data from three 6-week, double-blind, placebo-controlled studies of paliperidone ER in patients experiencing acute exacerbation was conducted. Regression analysis explored relationships between baseline/study characteristics and negative symptoms. Change in Positive and Negative Syndrome Scale (PANSS) negative factor score at endpoint was the dependent variable; explanatory variables included demographic and clinical characteristics. Path analysis determined direct and indirect effects of treatment on negative symptom change. Indirect mediators of negative symptom change in the model included changes in positive symptoms, anxiety/depression symptoms and movement disorders. Path analysis indicated that up to 33% of negative symptom improvement was a direct treatment effect. Indirect effects on negative symptoms were mediated through changes in positive symptoms (51%) and anxiety/depression symptoms (18%), whereas changes in movement disorders had a 2.1% inverse effect. Path analysis indicated that paliperidone ER has a direct effect on negative symptoms. Negative symptom improvement also was indirectly mediated via changes in positive and depressive symptoms.Keywords: antipsychotic, paliperidone ER, path analysis, psychotropic, schizophrenia Ibrahim TurkozCynthia A BossieBryan DirksCarla M CanusoDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 5, Pp 949-958 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ibrahim Turkoz Cynthia A Bossie Bryan Dirks Carla M Canuso Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia
description	Ibrahim Turkoz, Cynthia A Bossie, Bryan Dirks, Carla M CanusoOrtho-McNeil Janssen Scientific Affairs, LLC, Titusville, NJ, USAAbstract: Direct and indirect effects of the new psychotropic paliperidone extended-release (paliperidone ER) tablets on negative symptom improvement in schizophrenia were investigated using path analysis. A post hoc analysis of pooled data from three 6-week, double-blind, placebo-controlled studies of paliperidone ER in patients experiencing acute exacerbation was conducted. Regression analysis explored relationships between baseline/study characteristics and negative symptoms. Change in Positive and Negative Syndrome Scale (PANSS) negative factor score at endpoint was the dependent variable; explanatory variables included demographic and clinical characteristics. Path analysis determined direct and indirect effects of treatment on negative symptom change. Indirect mediators of negative symptom change in the model included changes in positive symptoms, anxiety/depression symptoms and movement disorders. Path analysis indicated that up to 33% of negative symptom improvement was a direct treatment effect. Indirect effects on negative symptoms were mediated through changes in positive symptoms (51%) and anxiety/depression symptoms (18%), whereas changes in movement disorders had a 2.1% inverse effect. Path analysis indicated that paliperidone ER has a direct effect on negative symptoms. Negative symptom improvement also was indirectly mediated via changes in positive and depressive symptoms.Keywords: antipsychotic, paliperidone ER, path analysis, psychotropic, schizophrenia
format	article
author	Ibrahim Turkoz Cynthia A Bossie Bryan Dirks Carla M Canuso
author_facet	Ibrahim Turkoz Cynthia A Bossie Bryan Dirks Carla M Canuso
author_sort	Ibrahim Turkoz
title	Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia
title_short	Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia
title_full	Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia
title_fullStr	Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia
title_full_unstemmed	Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia
title_sort	direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/a85737ed2de249969bd1778a236c12c1
work_keys_str_mv	AT ibrahimturkoz directandindirecteffectsofpaliperidoneextendedreleasetabletsonnegativesymptomsofschizophrenia AT cynthiaabossie directandindirecteffectsofpaliperidoneextendedreleasetabletsonnegativesymptomsofschizophrenia AT bryandirks directandindirecteffectsofpaliperidoneextendedreleasetabletsonnegativesymptomsofschizophrenia AT carlamcanuso directandindirecteffectsofpaliperidoneextendedreleasetabletsonnegativesymptomsofschizophrenia
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Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia

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