Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis

PURPOSE: Defining vascular calcification markers in patients on long-term hemodialysis (LTH) with type 2 diabetes mellitus (type 2 diabetes) and without type 2 diabetes. MATERIALS AND METHODS: The study was conducted in 82 patients with chronic kidney disease (CKD) (51 men, 31 women) on LTH, of whi...

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Autores principales:	Tatyana V. Archakova, Ludmila V. Nedosugova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2020
Materias:	type 2 diabetes mellitus vascular calcification long-term hemodialysis fibroblast growth factor 23 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/a8588a241a534d0c94d63d396f3f52eb
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spelling	oai:doaj.org-article:a8588a241a534d0c94d63d396f3f52eb2021-11-14T09:00:23ZFactors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis2072-03512072-037810.14341/DM10145https://doaj.org/article/a8588a241a534d0c94d63d396f3f52eb2020-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10145https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378PURPOSE: Defining vascular calcification markers in patients on long-term hemodialysis (LTH) with type 2 diabetes mellitus (type 2 diabetes) and without type 2 diabetes. MATERIALS AND METHODS: The study was conducted in 82 patients with chronic kidney disease (CKD) (51 men, 31 women) on LTH, of which 25 patients (10 men, 15 women) had type 2 diabetes and 57 people (33 men, 24 women) had no diabetes. All patients underwent evaluation of calcium-phosphate metabolism, control of intact PTH (iPTH), inorganic phosphorus, and total calcium. All patients were tested for the level of fibroblast growth factor-23 (FGF23) in blood serum using a multi-enzyme immunoassay kit, and the correlation between these parameters and the presence of vascular calcification was evaluated. RESULTS: A correlation was found between the severity of vascular calcification and the calcium-phosphate metabolism. In the group with type 2 diabetes, there is a correlation between the level of FGF23, iPTH, inorganic phosphorus and vascular calcification. There is also a correlation between the time on LTH and the increase in the level of FGF23 in patients with type 2 diabetes. CONCLUSION: We obtained data that can indicate a more pronounced change in the vascular wall in patients with type 2 diabetes on LTH in comparison with patients without diabetes mellitus on LTH, which allows to associate high cardiovascular mortality in patients with type 2 diabetes on LTH with accelerated development of vascular calcification.Tatyana V. ArchakovaLudmila V. NedosugovaEndocrinology Research Centrearticletype 2 diabetes mellitusvascular calcificationlong-term hemodialysisfibroblast growth factor 23Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 2, Pp 125-131 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus vascular calcification long-term hemodialysis fibroblast growth factor 23 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus vascular calcification long-term hemodialysis fibroblast growth factor 23 Nutritional diseases. Deficiency diseases RC620-627 Tatyana V. Archakova Ludmila V. Nedosugova Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis
description	PURPOSE: Defining vascular calcification markers in patients on long-term hemodialysis (LTH) with type 2 diabetes mellitus (type 2 diabetes) and without type 2 diabetes. MATERIALS AND METHODS: The study was conducted in 82 patients with chronic kidney disease (CKD) (51 men, 31 women) on LTH, of which 25 patients (10 men, 15 women) had type 2 diabetes and 57 people (33 men, 24 women) had no diabetes. All patients underwent evaluation of calcium-phosphate metabolism, control of intact PTH (iPTH), inorganic phosphorus, and total calcium. All patients were tested for the level of fibroblast growth factor-23 (FGF23) in blood serum using a multi-enzyme immunoassay kit, and the correlation between these parameters and the presence of vascular calcification was evaluated. RESULTS: A correlation was found between the severity of vascular calcification and the calcium-phosphate metabolism. In the group with type 2 diabetes, there is a correlation between the level of FGF23, iPTH, inorganic phosphorus and vascular calcification. There is also a correlation between the time on LTH and the increase in the level of FGF23 in patients with type 2 diabetes. CONCLUSION: We obtained data that can indicate a more pronounced change in the vascular wall in patients with type 2 diabetes on LTH in comparison with patients without diabetes mellitus on LTH, which allows to associate high cardiovascular mortality in patients with type 2 diabetes on LTH with accelerated development of vascular calcification.
format	article
author	Tatyana V. Archakova Ludmila V. Nedosugova
author_facet	Tatyana V. Archakova Ludmila V. Nedosugova
author_sort	Tatyana V. Archakova
title	Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis
title_short	Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis
title_full	Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis
title_fullStr	Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis
title_full_unstemmed	Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis
title_sort	factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis
publisher	Endocrinology Research Centre
publishDate	2020
url	https://doaj.org/article/a8588a241a534d0c94d63d396f3f52eb
work_keys_str_mv	AT tatyanavarchakova factorsofvascularcalcificationinpatientswithtype2diabetesmellitusonlongtermdialysis AT ludmilavnedosugova factorsofvascularcalcificationinpatientswithtype2diabetesmellitusonlongtermdialysis
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Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis

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