Transfer of DNA from Bacteria to Eukaryotes

ABSTRACT Historically, the members of the Agrobacterium genus have been considered the only bacterial species naturally able to transfer and integrate DNA into the genomes of their eukaryotic hosts. Yet, increasing evidence suggests that this ability to genetically transform eukaryotic host cells mi...

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Autores principales:	Benoît Lacroix, Vitaly Citovsky
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a859505de4714f9a8bd8543af455be9d
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spelling	oai:doaj.org-article:a859505de4714f9a8bd8543af455be9d2021-11-15T15:50:19ZTransfer of DNA from Bacteria to Eukaryotes10.1128/mBio.00863-162150-7511https://doaj.org/article/a859505de4714f9a8bd8543af455be9d2016-09-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00863-16https://doaj.org/toc/2150-7511ABSTRACT Historically, the members of the Agrobacterium genus have been considered the only bacterial species naturally able to transfer and integrate DNA into the genomes of their eukaryotic hosts. Yet, increasing evidence suggests that this ability to genetically transform eukaryotic host cells might be more widespread in the bacterial world. Indeed, analyses of accumulating genomic data reveal cases of horizontal gene transfer from bacteria to eukaryotes and suggest that it represents a significant force in adaptive evolution of eukaryotic species. Specifically, recent reports indicate that bacteria other than Agrobacterium, such as Bartonella henselae (a zoonotic pathogen), Rhizobium etli (a plant-symbiotic bacterium related to Agrobacterium), or even Escherichia coli, have the ability to genetically transform their host cells under laboratory conditions. This DNA transfer relies on type IV secretion systems (T4SSs), the molecular machines that transport macromolecules during conjugative plasmid transfer and also during transport of proteins and/or DNA to the eukaryotic recipient cells. In this review article, we explore the extent of possible transfer of genetic information from bacteria to eukaryotic cells as well as the evolutionary implications and potential applications of this transfer.Benoît LacroixVitaly CitovskyAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 4 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Benoît Lacroix Vitaly Citovsky Transfer of DNA from Bacteria to Eukaryotes
description	ABSTRACT Historically, the members of the Agrobacterium genus have been considered the only bacterial species naturally able to transfer and integrate DNA into the genomes of their eukaryotic hosts. Yet, increasing evidence suggests that this ability to genetically transform eukaryotic host cells might be more widespread in the bacterial world. Indeed, analyses of accumulating genomic data reveal cases of horizontal gene transfer from bacteria to eukaryotes and suggest that it represents a significant force in adaptive evolution of eukaryotic species. Specifically, recent reports indicate that bacteria other than Agrobacterium, such as Bartonella henselae (a zoonotic pathogen), Rhizobium etli (a plant-symbiotic bacterium related to Agrobacterium), or even Escherichia coli, have the ability to genetically transform their host cells under laboratory conditions. This DNA transfer relies on type IV secretion systems (T4SSs), the molecular machines that transport macromolecules during conjugative plasmid transfer and also during transport of proteins and/or DNA to the eukaryotic recipient cells. In this review article, we explore the extent of possible transfer of genetic information from bacteria to eukaryotic cells as well as the evolutionary implications and potential applications of this transfer.
format	article
author	Benoît Lacroix Vitaly Citovsky
author_facet	Benoît Lacroix Vitaly Citovsky
author_sort	Benoît Lacroix
title	Transfer of DNA from Bacteria to Eukaryotes
title_short	Transfer of DNA from Bacteria to Eukaryotes
title_full	Transfer of DNA from Bacteria to Eukaryotes
title_fullStr	Transfer of DNA from Bacteria to Eukaryotes
title_full_unstemmed	Transfer of DNA from Bacteria to Eukaryotes
title_sort	transfer of dna from bacteria to eukaryotes
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/a859505de4714f9a8bd8543af455be9d
work_keys_str_mv	AT benoitlacroix transferofdnafrombacteriatoeukaryotes AT vitalycitovsky transferofdnafrombacteriatoeukaryotes
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Transfer of DNA from Bacteria to Eukaryotes

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