Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.

<h4>Background</h4>The microbiome of the male urogenital tract is poorly described but it has been suggested that bacterial colonization of the male urethra might impact risk of sexually transmitted infection (STI). Previous cultivation-dependent studies showed that a variety of non-path...

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Autores principales:	David E Nelson, Barbara Van Der Pol, Qunfeng Dong, Kashi V Revanna, Baochang Fan, Shraddha Easwaran, Erica Sodergren, George M Weinstock, Lixia Diao, J Dennis Fortenberry
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a85a91129db14182b7b4128aa6934644
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spelling	oai:doaj.org-article:a85a91129db14182b7b4128aa69346442021-11-18T07:36:34ZCharacteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.1932-620310.1371/journal.pone.0014116https://doaj.org/article/a85a91129db14182b7b4128aa69346442010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21124791/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The microbiome of the male urogenital tract is poorly described but it has been suggested that bacterial colonization of the male urethra might impact risk of sexually transmitted infection (STI). Previous cultivation-dependent studies showed that a variety of non-pathogenic bacteria colonize the urethra but did not thoroughly characterize these microbiomes or establish links between the compositions of urethral microbiomes and STI.<h4>Methodology/findings</h4>Here, we used 16S rRNA PCR and sequencing to identify bacteria in urine specimens collected from men who lacked symptoms of urethral inflammation but who differed in status for STI. All of the urine samples contained multiple bacterial genera and many contained taxa that colonize the human vagina. Uncultivated bacteria associated with female genital tract pathology were abundant in specimens from men who had STI.<h4>Conclusions</h4>Urine microbiomes from men with STI were dominated by fastidious, anaerobic and uncultivated bacteria. The same taxa were rare in STI negative individuals. Our findings suggest that the composition of male urine microbiomes is related to STI.David E NelsonBarbara Van Der PolQunfeng DongKashi V RevannaBaochang FanShraddha EaswaranErica SodergrenGeorge M WeinstockLixia DiaoJ Dennis FortenberryPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e14116 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David E Nelson Barbara Van Der Pol Qunfeng Dong Kashi V Revanna Baochang Fan Shraddha Easwaran Erica Sodergren George M Weinstock Lixia Diao J Dennis Fortenberry Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.
description	<h4>Background</h4>The microbiome of the male urogenital tract is poorly described but it has been suggested that bacterial colonization of the male urethra might impact risk of sexually transmitted infection (STI). Previous cultivation-dependent studies showed that a variety of non-pathogenic bacteria colonize the urethra but did not thoroughly characterize these microbiomes or establish links between the compositions of urethral microbiomes and STI.<h4>Methodology/findings</h4>Here, we used 16S rRNA PCR and sequencing to identify bacteria in urine specimens collected from men who lacked symptoms of urethral inflammation but who differed in status for STI. All of the urine samples contained multiple bacterial genera and many contained taxa that colonize the human vagina. Uncultivated bacteria associated with female genital tract pathology were abundant in specimens from men who had STI.<h4>Conclusions</h4>Urine microbiomes from men with STI were dominated by fastidious, anaerobic and uncultivated bacteria. The same taxa were rare in STI negative individuals. Our findings suggest that the composition of male urine microbiomes is related to STI.
format	article
author	David E Nelson Barbara Van Der Pol Qunfeng Dong Kashi V Revanna Baochang Fan Shraddha Easwaran Erica Sodergren George M Weinstock Lixia Diao J Dennis Fortenberry
author_facet	David E Nelson Barbara Van Der Pol Qunfeng Dong Kashi V Revanna Baochang Fan Shraddha Easwaran Erica Sodergren George M Weinstock Lixia Diao J Dennis Fortenberry
author_sort	David E Nelson
title	Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.
title_short	Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.
title_full	Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.
title_fullStr	Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.
title_full_unstemmed	Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.
title_sort	characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/a85a91129db14182b7b4128aa6934644
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Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection.

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