Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats

Lead acetate associated tissue injury has been linked to altered antioxidant defenses, hyperuricemia and inflammation. We hypothesized that watermelon rind extract, would ameliorate lead acetate-induced hepato-renal injury.Thirty Male Wistar rats received distilled water, lead acetate (Pb; 5 mg/kg)...

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Autores principales:	Olugbenga S. Michael, Olubayode Bamidele, Pamela Ogheneovo, Temitope A. Ariyo, Lawrence D. Adedayo, Olufemi I. Oluranti, Elizabeth O. Soladoye, Charles O. Adetunji, Funmileyi O. Awobajo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Watermelon Uric acid Nitric oxide Oxidative stress Lead acetate Physiology QP1-981 Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/a86031d8f2af42aea48f75a76f93fa40
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spelling	oai:doaj.org-article:a86031d8f2af42aea48f75a76f93fa402021-11-20T05:13:35ZWatermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats2665-944110.1016/j.crphys.2021.11.002https://doaj.org/article/a86031d8f2af42aea48f75a76f93fa402021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2665944121000304https://doaj.org/toc/2665-9441Lead acetate associated tissue injury has been linked to altered antioxidant defenses, hyperuricemia and inflammation. We hypothesized that watermelon rind extract, would ameliorate lead acetate-induced hepato-renal injury.Thirty Male Wistar rats received distilled water, lead acetate (Pb; 5 mg/kg) with or without watermelon rind extract (WM; 400 mg/kg; WM + Pb; 15 days of WM pretreatment); Pb + WM (15 days of WM post treatment) and simultaneous treatment (WM-Pb) for 30 days.Lead toxicity led to elevated serum malondialdehyde, creatinine, urea, uric acid, lactate dehydrogenase, liver injury enzymes, as well as decreased body weight. Decreased serum levels of reduced glutathione, nitric oxide, total protein and glutathione peroxidase activity was also observed. However, these alterations were ameliorated by watermelon rind extract in lead acetate-treated rats.Watermelon rind ethanol extract protects against lead acetate-induced hepato-renal injury through improved antioxidant defenses at least in part, via uric acid/nitric oxide-dependent pathway signifying the health benefits of this agricultural waste and a potential for waste recycling while limiting environmental pollution.Olugbenga S. MichaelOlubayode BamidelePamela OgheneovoTemitope A. AriyoLawrence D. AdedayoOlufemi I. OlurantiElizabeth O. SoladoyeCharles O. AdetunjiFunmileyi O. AwobajoElsevierarticleWatermelonUric acidNitric oxideOxidative stressLead acetatePhysiologyQP1-981Specialties of internal medicineRC581-951ENCurrent Research in Physiology, Vol 4, Iss , Pp 252-259 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Watermelon Uric acid Nitric oxide Oxidative stress Lead acetate Physiology QP1-981 Specialties of internal medicine RC581-951
spellingShingle	Watermelon Uric acid Nitric oxide Oxidative stress Lead acetate Physiology QP1-981 Specialties of internal medicine RC581-951 Olugbenga S. Michael Olubayode Bamidele Pamela Ogheneovo Temitope A. Ariyo Lawrence D. Adedayo Olufemi I. Oluranti Elizabeth O. Soladoye Charles O. Adetunji Funmileyi O. Awobajo Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats
description	Lead acetate associated tissue injury has been linked to altered antioxidant defenses, hyperuricemia and inflammation. We hypothesized that watermelon rind extract, would ameliorate lead acetate-induced hepato-renal injury.Thirty Male Wistar rats received distilled water, lead acetate (Pb; 5 mg/kg) with or without watermelon rind extract (WM; 400 mg/kg; WM + Pb; 15 days of WM pretreatment); Pb + WM (15 days of WM post treatment) and simultaneous treatment (WM-Pb) for 30 days.Lead toxicity led to elevated serum malondialdehyde, creatinine, urea, uric acid, lactate dehydrogenase, liver injury enzymes, as well as decreased body weight. Decreased serum levels of reduced glutathione, nitric oxide, total protein and glutathione peroxidase activity was also observed. However, these alterations were ameliorated by watermelon rind extract in lead acetate-treated rats.Watermelon rind ethanol extract protects against lead acetate-induced hepato-renal injury through improved antioxidant defenses at least in part, via uric acid/nitric oxide-dependent pathway signifying the health benefits of this agricultural waste and a potential for waste recycling while limiting environmental pollution.
format	article
author	Olugbenga S. Michael Olubayode Bamidele Pamela Ogheneovo Temitope A. Ariyo Lawrence D. Adedayo Olufemi I. Oluranti Elizabeth O. Soladoye Charles O. Adetunji Funmileyi O. Awobajo
author_facet	Olugbenga S. Michael Olubayode Bamidele Pamela Ogheneovo Temitope A. Ariyo Lawrence D. Adedayo Olufemi I. Oluranti Elizabeth O. Soladoye Charles O. Adetunji Funmileyi O. Awobajo
author_sort	Olugbenga S. Michael
title	Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats
title_short	Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats
title_full	Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats
title_fullStr	Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats
title_full_unstemmed	Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats
title_sort	watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male wistar rats
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a86031d8f2af42aea48f75a76f93fa40
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Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats

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