A common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis.
<h4>Background</h4>Genome-wide association studies have reported that a polymorphism near the estrogen receptor gene (ESR1) (rs2046210) is associated with a risk of breast cancer, with the A allele conferring an increased risk. However, considering the controversial results from more rec...
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2012
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oai:doaj.org-article:a860c0e647b945a695a3d277105078212021-11-18T08:04:37ZA common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis.1932-620310.1371/journal.pone.0052445https://doaj.org/article/a860c0e647b945a695a3d277105078212012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272245/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Genome-wide association studies have reported that a polymorphism near the estrogen receptor gene (ESR1) (rs2046210) is associated with a risk of breast cancer, with the A allele conferring an increased risk. However, considering the controversial results from more recent replicated studies, we conducted a case-control study in an independent Chinese Han population and a meta-analysis to clarify the association of this polymorphism with breast cancer risk.<h4>Method and findings</h4>A hospital-based case-control study including 461 cases and 537 controls from a Chinese Han population was conducted initially, and this study showed that the rs2046210 A allele was significantly associated with breast cancer risk, with an OR of 1.32 (95% CI = 1.10-1.59). Subsequently, a meta-analysis integrating the current study and previous publications with a total of 53,379 cases and 55,493 controls was performed to further confirm our findings. Similarly, a significant association between this polymorphism and breast cancer risk was also observed in the overall population especially among Asians, with ORs for per A allele of 1.14 (95% CI = 1.10-1.18) in the overall population and 1.27 (95% CI = 1.23-1.31) in the Asian population.<h4>Conclusion</h4>Our results provide strong evidence to support that the common polymorphism near the ESR1 gene, rs2046210, is associated with an increased risk of breast cancer in Asian and European populations but not in Africans, although the biological mechanisms need to be further investigated.Hui GuoJie MingChunping LiuZhi LiNing ZhangHongtao ChengWei WangWei ShiNa ShenQunzi ZhaoDapeng LiPengfei YiLongqiang WangRui WangYue XinXiangwang ZhaoXiu NieTao HuangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52445 (2012) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Hui Guo Jie Ming Chunping Liu Zhi Li Ning Zhang Hongtao Cheng Wei Wang Wei Shi Na Shen Qunzi Zhao Dapeng Li Pengfei Yi Longqiang Wang Rui Wang Yue Xin Xiangwang Zhao Xiu Nie Tao Huang A common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis. |
| description |
<h4>Background</h4>Genome-wide association studies have reported that a polymorphism near the estrogen receptor gene (ESR1) (rs2046210) is associated with a risk of breast cancer, with the A allele conferring an increased risk. However, considering the controversial results from more recent replicated studies, we conducted a case-control study in an independent Chinese Han population and a meta-analysis to clarify the association of this polymorphism with breast cancer risk.<h4>Method and findings</h4>A hospital-based case-control study including 461 cases and 537 controls from a Chinese Han population was conducted initially, and this study showed that the rs2046210 A allele was significantly associated with breast cancer risk, with an OR of 1.32 (95% CI = 1.10-1.59). Subsequently, a meta-analysis integrating the current study and previous publications with a total of 53,379 cases and 55,493 controls was performed to further confirm our findings. Similarly, a significant association between this polymorphism and breast cancer risk was also observed in the overall population especially among Asians, with ORs for per A allele of 1.14 (95% CI = 1.10-1.18) in the overall population and 1.27 (95% CI = 1.23-1.31) in the Asian population.<h4>Conclusion</h4>Our results provide strong evidence to support that the common polymorphism near the ESR1 gene, rs2046210, is associated with an increased risk of breast cancer in Asian and European populations but not in Africans, although the biological mechanisms need to be further investigated. |
| format |
article |
| author |
Hui Guo Jie Ming Chunping Liu Zhi Li Ning Zhang Hongtao Cheng Wei Wang Wei Shi Na Shen Qunzi Zhao Dapeng Li Pengfei Yi Longqiang Wang Rui Wang Yue Xin Xiangwang Zhao Xiu Nie Tao Huang |
| author_facet |
Hui Guo Jie Ming Chunping Liu Zhi Li Ning Zhang Hongtao Cheng Wei Wang Wei Shi Na Shen Qunzi Zhao Dapeng Li Pengfei Yi Longqiang Wang Rui Wang Yue Xin Xiangwang Zhao Xiu Nie Tao Huang |
| author_sort |
Hui Guo |
| title |
A common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis. |
| title_short |
A common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis. |
| title_full |
A common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis. |
| title_fullStr |
A common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis. |
| title_full_unstemmed |
A common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis. |
| title_sort |
common polymorphism near the esr1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/a860c0e647b945a695a3d27710507821 |
| work_keys_str_mv |
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