Associations of informant-based sleep reports with Alzheimer’s disease pathologies

Associations of informant-based sleep reports with Alzheimer’s disease pathologies

Sepideh Shokouhi On behalf of The Alzheimer’s Disease Neuroimaging InitiativeCenter for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, USACorrespondence: Sepideh ShokouhiDepartment of Psychiatry and Behavioral Sciences...

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Autor principal: Shokouhi S
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Aβ
tau
positron emission tomography
mild cognitive impairment
sleep
Neuropsychiatric Inventory
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/a861706ffd6b404884b92ddb2cad244e
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spelling oai:doaj.org-article:a861706ffd6b404884b92ddb2cad244e2021-12-02T05:42:46ZAssociations of informant-based sleep reports with Alzheimer’s disease pathologies1178-1998https://doaj.org/article/a861706ffd6b404884b92ddb2cad244e2019-09-01T00:00:00Zhttps://www.dovepress.com/associations-of-informant-based-sleep-reports-with-alzheimers-disease--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Sepideh Shokouhi On behalf of The Alzheimer’s Disease Neuroimaging InitiativeCenter for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, USACorrespondence: Sepideh ShokouhiDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 189 B Kenner Ave, Nashville, TN 37205, USATel +1 631 513 0547Email sepideh.shokouhi@vanderbilt.eduPurpose: Recent studies have found associations of increased brain amyloid beta (Aβ) accumulation and several abnormal sleep-wake patterns, including shorter latency and increased fragmentation in preclinical Alzheimer’s disease (AD). There is little known about the relationship between sleep and tau. The objective of this study was to understand the associations of both tau and Aβ with early signs of sleep and night-time behavior changes in clinically normal elderly adults. Specifically, we have addressed the question of how informant-based subjective sleep reports are linked to regional [18F]flortaucipir and [18F]florbetapir uptake.Methods: Imaging and behavioral data from 35 subjects were obtained from the Alzheimer’s Disease Neuroimaging Initiative. The Neuropsychiatric Inventory Sleep (NPI-sleep) Questionnaire was used to assess the sleep and night-time behavior changes. Regional tau-positron emission tomography (PET) (entorhinal, brainstem) and Aβ-PET (posterior cingulate, precuneus, medial orbitofrontal) uptake values were calculated. A series of linear regression analyses were used to determine the combination of sleep symptoms that built the best models to predict each pathology.Results: Informant-based reports of abnormal night-time behavior (NPI questions k3, k5, and k8) were significantly associated with increased entorhinal tau and Aβ (all regions) accumulation. Interestingly, informant-based reports of sleep deficiencies without abnormal nigh-time activity (NPI questions k1, k2, and k6) were negatively associated with entorhinal tau burden.Conclusion: Detection of abnormal night-time behaviors (wandering, pacing, other inappropriate activities) by family members indicates early signs of both AD pathologies and may encourage the affected individuals to seek help by health care providers for detailed cognitive/neurobehavioral assessments.Keywords: Aβ, tau, positron emission tomography, mild cognitive impairment, sleep, neuropsychiatric inventoryShokouhi SDove Medical PressarticleAβtaupositron emission tomographymild cognitive impairmentsleepNeuropsychiatric InventoryGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1631-1642 (2019)
institution DOAJ
collection DOAJ
language EN
topic Aβ
tau
positron emission tomography
mild cognitive impairment
sleep
Neuropsychiatric Inventory
Geriatrics
RC952-954.6
spellingShingle Aβ
tau
positron emission tomography
mild cognitive impairment
sleep
Neuropsychiatric Inventory
Geriatrics
RC952-954.6
Shokouhi S
Associations of informant-based sleep reports with Alzheimer’s disease pathologies
description Sepideh Shokouhi On behalf of The Alzheimer’s Disease Neuroimaging InitiativeCenter for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, USACorrespondence: Sepideh ShokouhiDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 189 B Kenner Ave, Nashville, TN 37205, USATel +1 631 513 0547Email sepideh.shokouhi@vanderbilt.eduPurpose: Recent studies have found associations of increased brain amyloid beta (Aβ) accumulation and several abnormal sleep-wake patterns, including shorter latency and increased fragmentation in preclinical Alzheimer’s disease (AD). There is little known about the relationship between sleep and tau. The objective of this study was to understand the associations of both tau and Aβ with early signs of sleep and night-time behavior changes in clinically normal elderly adults. Specifically, we have addressed the question of how informant-based subjective sleep reports are linked to regional [18F]flortaucipir and [18F]florbetapir uptake.Methods: Imaging and behavioral data from 35 subjects were obtained from the Alzheimer’s Disease Neuroimaging Initiative. The Neuropsychiatric Inventory Sleep (NPI-sleep) Questionnaire was used to assess the sleep and night-time behavior changes. Regional tau-positron emission tomography (PET) (entorhinal, brainstem) and Aβ-PET (posterior cingulate, precuneus, medial orbitofrontal) uptake values were calculated. A series of linear regression analyses were used to determine the combination of sleep symptoms that built the best models to predict each pathology.Results: Informant-based reports of abnormal night-time behavior (NPI questions k3, k5, and k8) were significantly associated with increased entorhinal tau and Aβ (all regions) accumulation. Interestingly, informant-based reports of sleep deficiencies without abnormal nigh-time activity (NPI questions k1, k2, and k6) were negatively associated with entorhinal tau burden.Conclusion: Detection of abnormal night-time behaviors (wandering, pacing, other inappropriate activities) by family members indicates early signs of both AD pathologies and may encourage the affected individuals to seek help by health care providers for detailed cognitive/neurobehavioral assessments.Keywords: Aβ, tau, positron emission tomography, mild cognitive impairment, sleep, neuropsychiatric inventory
format article
author Shokouhi S
author_facet Shokouhi S
author_sort Shokouhi S
title Associations of informant-based sleep reports with Alzheimer’s disease pathologies
title_short Associations of informant-based sleep reports with Alzheimer’s disease pathologies
title_full Associations of informant-based sleep reports with Alzheimer’s disease pathologies
title_fullStr Associations of informant-based sleep reports with Alzheimer’s disease pathologies
title_full_unstemmed Associations of informant-based sleep reports with Alzheimer’s disease pathologies
title_sort associations of informant-based sleep reports with alzheimer’s disease pathologies
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/a861706ffd6b404884b92ddb2cad244e
work_keys_str_mv AT shokouhis associationsofinformantbasedsleepreportswithalzheimerrsquosdiseasepathologies
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