Correlation between Iron Status and Simple Febrile Seizures in Children

Background: Febrile seizures are non-epileptic types of seizure that occur frequently during early childhood. Multiple factors are implicated in the pathogenesis of these types of seizures. Iron deficiency might play as an etiological or, at least, augmenting factor in the development of febrile sei...

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Autores principales:	Marwa Elkafafy, Magdy Sakr, Mohamed Elsamanoudy, hesham abd al-samee
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	fever seizures iron anemia febrile seizures Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a861a06ce54c435c9ec35dbcc7a30c43
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spelling	oai:doaj.org-article:a861a06ce54c435c9ec35dbcc7a30c432021-12-02T17:05:59ZCorrelation between Iron Status and Simple Febrile Seizures in Children2636-41742682-378010.21608/ijma.2021.79064.1320https://doaj.org/article/a861a06ce54c435c9ec35dbcc7a30c432021-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_186029_8a360b69fef9dd38bef8343c39f6a359.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Febrile seizures are non-epileptic types of seizure that occur frequently during early childhood. Multiple factors are implicated in the pathogenesis of these types of seizures. Iron deficiency might play as an etiological or, at least, augmenting factor in the development of febrile seizures. Objective: To study iron status among children with simple febrile seizures, and to estimate the prevalence of iron deficiency between them. Patients and methods: A case-control study included 100 febrile children aged 6 months to 60 months, and were ascribed to 2 groups; 50 children with simple febrile seizures [case group], and 50 children who had febrile disease without occurrence of seizures [control group]. Venous samples were obtained for the analysis of complete blood count, and iron indices [serum ferritin, serum iron and total iron binding capacity]. Results: The peak temperature was significantly elevated among the case group [P=0.03]. Regarding iron profile, compared to controls, the case group had significantly lower iron [54.24±16.04 vs. 62.6±16.02; P=0.011], and lower ferritin [37.612±19.85 vs. 80.624±31.57; P <0.001]. Correlation analysis revealed a significant negative correlation between serum ferritin and frequency of febrile seizures [P=0.025] Conclusions: Iron deficiency and iron deficiency anemia were more common among children with simple febrile seizures, and they were associated with increase in the duration and frequency of seizures. Special attention should be paid for the assessment of iron status among children with febrile seizures.Marwa ElkafafyMagdy SakrMohamed Elsamanoudyhesham abd al-sameeAl-Azhar University, Faculty of Medicine (Damietta)articlefeverseizuresironanemiafebrile seizuresMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 3, Pp 1714-1718 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fever seizures iron anemia febrile seizures Medicine (General) R5-920
spellingShingle	fever seizures iron anemia febrile seizures Medicine (General) R5-920 Marwa Elkafafy Magdy Sakr Mohamed Elsamanoudy hesham abd al-samee Correlation between Iron Status and Simple Febrile Seizures in Children
description	Background: Febrile seizures are non-epileptic types of seizure that occur frequently during early childhood. Multiple factors are implicated in the pathogenesis of these types of seizures. Iron deficiency might play as an etiological or, at least, augmenting factor in the development of febrile seizures. Objective: To study iron status among children with simple febrile seizures, and to estimate the prevalence of iron deficiency between them. Patients and methods: A case-control study included 100 febrile children aged 6 months to 60 months, and were ascribed to 2 groups; 50 children with simple febrile seizures [case group], and 50 children who had febrile disease without occurrence of seizures [control group]. Venous samples were obtained for the analysis of complete blood count, and iron indices [serum ferritin, serum iron and total iron binding capacity]. Results: The peak temperature was significantly elevated among the case group [P=0.03]. Regarding iron profile, compared to controls, the case group had significantly lower iron [54.24±16.04 vs. 62.6±16.02; P=0.011], and lower ferritin [37.612±19.85 vs. 80.624±31.57; P <0.001]. Correlation analysis revealed a significant negative correlation between serum ferritin and frequency of febrile seizures [P=0.025] Conclusions: Iron deficiency and iron deficiency anemia were more common among children with simple febrile seizures, and they were associated with increase in the duration and frequency of seizures. Special attention should be paid for the assessment of iron status among children with febrile seizures.
format	article
author	Marwa Elkafafy Magdy Sakr Mohamed Elsamanoudy hesham abd al-samee
author_facet	Marwa Elkafafy Magdy Sakr Mohamed Elsamanoudy hesham abd al-samee
author_sort	Marwa Elkafafy
title	Correlation between Iron Status and Simple Febrile Seizures in Children
title_short	Correlation between Iron Status and Simple Febrile Seizures in Children
title_full	Correlation between Iron Status and Simple Febrile Seizures in Children
title_fullStr	Correlation between Iron Status and Simple Febrile Seizures in Children
title_full_unstemmed	Correlation between Iron Status and Simple Febrile Seizures in Children
title_sort	correlation between iron status and simple febrile seizures in children
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/a861a06ce54c435c9ec35dbcc7a30c43
work_keys_str_mv	AT marwaelkafafy correlationbetweenironstatusandsimplefebrileseizuresinchildren AT magdysakr correlationbetweenironstatusandsimplefebrileseizuresinchildren AT mohamedelsamanoudy correlationbetweenironstatusandsimplefebrileseizuresinchildren AT heshamabdalsamee correlationbetweenironstatusandsimplefebrileseizuresinchildren
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Correlation between Iron Status and Simple Febrile Seizures in Children

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