MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS

Host-pathogen relations were analyzed on basis of the results of examinations of 42 patients with newly diagnosed, previously untreated infiltrative pulmonary tuberculosis (IPT) with regard for the biological characteristics of Mycobacterium tuberculosis (MBT) and the biomarkers of the inflammatory...

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Autores principales:	O. T. Titarenko, M. E. Dyakova, O. A. Manicheva, D. S. Esmedlyaeva, M. Z. Dogonadze, N. P. Alexeyeva, T. L. Perova, N. N. Melnikova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	tuberculosis acute phase proteins genotype virulence Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/a8623bd2d7fb4c5aab9462d1d62047af
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spelling	oai:doaj.org-article:a8623bd2d7fb4c5aab9462d1d62047af2021-11-22T07:09:46ZMYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS2220-76192313-739810.15789/2220-7619-2014-3-221-228https://doaj.org/article/a8623bd2d7fb4c5aab9462d1d62047af2014-08-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/180https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Host-pathogen relations were analyzed on basis of the results of examinations of 42 patients with newly diagnosed, previously untreated infiltrative pulmonary tuberculosis (IPT) with regard for the biological characteristics of Mycobacterium tuberculosis (MBT) and the biomarkers of the inflammatory reaction — the acute phase proteins (APPs). The genotypes of MBT (Beijing and the others) and the efficacy of threeonth antituberculosis therapy were used as the grouping factors. Genotype Beijing MBT patients were significantly often characterised by multiple drug resistant, had widespread pulmonary damage and association of MBT cytoxicity with the effect of therapy. The patients with the best postreatment effect had initial (pretreatment) APPs levels in the range of the referent ones. These conclusions were confirmed by analysis of the correlation pleads of the characteristics of the “host-pathogen” system and their discriminant analysis with regard for MBT genotypes and results of antituberculosis three-month therapy. It was shown that the constellation of four host’s APP characteristics (haptoglobin, ceruloplasmin, elastase and adenoaminase activities) has above 90% prognostic efficacy of treatment in spite of MBT genotype. It is suggested that in IPT patients the first component of the “host-pathogen” system reflecting the reaction of the patient’s organism to the MBT induced inflammatory process is more prognostically important.O. T. TitarenkoM. E. DyakovaO. A. ManichevaD. S. EsmedlyaevaM. Z. DogonadzeN. P. AlexeyevaT. L. PerovaN. N. MelnikovaSankt-Peterburg : NIIÈM imeni Pasteraarticletuberculosisacute phase proteinsgenotypevirulenceInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 3, Pp 221-228 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis acute phase proteins genotype virulence Infectious and parasitic diseases RC109-216
spellingShingle	tuberculosis acute phase proteins genotype virulence Infectious and parasitic diseases RC109-216 O. T. Titarenko M. E. Dyakova O. A. Manicheva D. S. Esmedlyaeva M. Z. Dogonadze N. P. Alexeyeva T. L. Perova N. N. Melnikova MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS
description	Host-pathogen relations were analyzed on basis of the results of examinations of 42 patients with newly diagnosed, previously untreated infiltrative pulmonary tuberculosis (IPT) with regard for the biological characteristics of Mycobacterium tuberculosis (MBT) and the biomarkers of the inflammatory reaction — the acute phase proteins (APPs). The genotypes of MBT (Beijing and the others) and the efficacy of threeonth antituberculosis therapy were used as the grouping factors. Genotype Beijing MBT patients were significantly often characterised by multiple drug resistant, had widespread pulmonary damage and association of MBT cytoxicity with the effect of therapy. The patients with the best postreatment effect had initial (pretreatment) APPs levels in the range of the referent ones. These conclusions were confirmed by analysis of the correlation pleads of the characteristics of the “host-pathogen” system and their discriminant analysis with regard for MBT genotypes and results of antituberculosis three-month therapy. It was shown that the constellation of four host’s APP characteristics (haptoglobin, ceruloplasmin, elastase and adenoaminase activities) has above 90% prognostic efficacy of treatment in spite of MBT genotype. It is suggested that in IPT patients the first component of the “host-pathogen” system reflecting the reaction of the patient’s organism to the MBT induced inflammatory process is more prognostically important.
format	article
author	O. T. Titarenko M. E. Dyakova O. A. Manicheva D. S. Esmedlyaeva M. Z. Dogonadze N. P. Alexeyeva T. L. Perova N. N. Melnikova
author_facet	O. T. Titarenko M. E. Dyakova O. A. Manicheva D. S. Esmedlyaeva M. Z. Dogonadze N. P. Alexeyeva T. L. Perova N. N. Melnikova
author_sort	O. T. Titarenko
title	MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS
title_short	MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS
title_full	MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS
title_fullStr	MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS
title_full_unstemmed	MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS
title_sort	mycobacterium tuberculosis biological properties and characteristics of the inflammatory reaction in patients with infiltrative pulmonary tuberculosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/a8623bd2d7fb4c5aab9462d1d62047af
work_keys_str_mv	AT ottitarenko mycobacteriumtuberculosisbiologicalpropertiesandcharacteristicsoftheinflammatoryreactioninpatientswithinfiltrativepulmonarytuberculosis AT medyakova mycobacteriumtuberculosisbiologicalpropertiesandcharacteristicsoftheinflammatoryreactioninpatientswithinfiltrativepulmonarytuberculosis AT oamanicheva mycobacteriumtuberculosisbiologicalpropertiesandcharacteristicsoftheinflammatoryreactioninpatientswithinfiltrativepulmonarytuberculosis AT dsesmedlyaeva mycobacteriumtuberculosisbiologicalpropertiesandcharacteristicsoftheinflammatoryreactioninpatientswithinfiltrativepulmonarytuberculosis AT mzdogonadze mycobacteriumtuberculosisbiologicalpropertiesandcharacteristicsoftheinflammatoryreactioninpatientswithinfiltrativepulmonarytuberculosis AT npalexeyeva mycobacteriumtuberculosisbiologicalpropertiesandcharacteristicsoftheinflammatoryreactioninpatientswithinfiltrativepulmonarytuberculosis AT tlperova mycobacteriumtuberculosisbiologicalpropertiesandcharacteristicsoftheinflammatoryreactioninpatientswithinfiltrativepulmonarytuberculosis AT nnmelnikova mycobacteriumtuberculosisbiologicalpropertiesandcharacteristicsoftheinflammatoryreactioninpatientswithinfiltrativepulmonarytuberculosis
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MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS

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