Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients

NMDA receptor: Enzyme breaks down ion channel activator in schizophrenic brain Altered metabolism of an amino acid activator of ion channels in the brain could explain dysfunctional nerve signaling in schizophrenia. Researchers in Italy led by Alessandro Usiello from Ceinge Biotecnologie Avanzate an...

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Autores principales:	Tommaso Nuzzo, Silvia Sacchi, Francesco Errico, Simona Keller, Orazio Palumbo, Ermanno Florio, Daniela Punzo, Francesco Napolitano, Massimiliano Copetti, Massimo Carella, Lorenzo Chiariotti, Alessandro Bertolino, Loredano Pollegioni, Alessandro Usiello
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/a86308ddf58444f9aee77aabea30e675
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spelling	oai:doaj.org-article:a86308ddf58444f9aee77aabea30e6752021-12-02T11:51:10ZDecreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients10.1038/s41537-017-0015-72334-265Xhttps://doaj.org/article/a86308ddf58444f9aee77aabea30e6752017-04-01T00:00:00Zhttps://doi.org/10.1038/s41537-017-0015-7https://doaj.org/toc/2334-265XNMDA receptor: Enzyme breaks down ion channel activator in schizophrenic brain Altered metabolism of an amino acid activator of ion channels in the brain could explain dysfunctional nerve signaling in schizophrenia. Researchers in Italy led by Alessandro Usiello from Ceinge Biotecnologie Avanzate and Loredano Pollegioni from the University of Insubria measured the levels of two amino acids—D-aspartate and D-serine—in post-mortem tissues taken from two brain regions of patients with and without schizophrenia. Both amino acids activate the N-methyl D-aspartate receptor, which is known to be less active in people with schizophrenia. The researchers found a mild increase in D-serine levels but a major decrease in D-aspartate in the schizophrenia patients’ dorsolateral prefrontal cortex (DLPFC), a memory and reasoning part of the brain, but not in the hippocampus. They also documented a greater activity of the enzyme responsible for D-aspartate breakdown in the DLPFC.Tommaso NuzzoSilvia SacchiFrancesco ErricoSimona KellerOrazio PalumboErmanno FlorioDaniela PunzoFrancesco NapolitanoMassimiliano CopettiMassimo CarellaLorenzo ChiariottiAlessandro BertolinoLoredano PollegioniAlessandro UsielloNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 3, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Tommaso Nuzzo Silvia Sacchi Francesco Errico Simona Keller Orazio Palumbo Ermanno Florio Daniela Punzo Francesco Napolitano Massimiliano Copetti Massimo Carella Lorenzo Chiariotti Alessandro Bertolino Loredano Pollegioni Alessandro Usiello Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
description	NMDA receptor: Enzyme breaks down ion channel activator in schizophrenic brain Altered metabolism of an amino acid activator of ion channels in the brain could explain dysfunctional nerve signaling in schizophrenia. Researchers in Italy led by Alessandro Usiello from Ceinge Biotecnologie Avanzate and Loredano Pollegioni from the University of Insubria measured the levels of two amino acids—D-aspartate and D-serine—in post-mortem tissues taken from two brain regions of patients with and without schizophrenia. Both amino acids activate the N-methyl D-aspartate receptor, which is known to be less active in people with schizophrenia. The researchers found a mild increase in D-serine levels but a major decrease in D-aspartate in the schizophrenia patients’ dorsolateral prefrontal cortex (DLPFC), a memory and reasoning part of the brain, but not in the hippocampus. They also documented a greater activity of the enzyme responsible for D-aspartate breakdown in the DLPFC.
format	article
author	Tommaso Nuzzo Silvia Sacchi Francesco Errico Simona Keller Orazio Palumbo Ermanno Florio Daniela Punzo Francesco Napolitano Massimiliano Copetti Massimo Carella Lorenzo Chiariotti Alessandro Bertolino Loredano Pollegioni Alessandro Usiello
author_facet	Tommaso Nuzzo Silvia Sacchi Francesco Errico Simona Keller Orazio Palumbo Ermanno Florio Daniela Punzo Francesco Napolitano Massimiliano Copetti Massimo Carella Lorenzo Chiariotti Alessandro Bertolino Loredano Pollegioni Alessandro Usiello
author_sort	Tommaso Nuzzo
title	Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
title_short	Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
title_full	Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
title_fullStr	Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
title_full_unstemmed	Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
title_sort	decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a86308ddf58444f9aee77aabea30e675
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Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients

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