Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community

Abstract Telomere length (TL) is a marker of ageing and mitochondrial DNA (mtDNA) is an early marker of inflammation caused by oxidative stress. We determined TL and mtDNA content among active pulmonary tuberculosis (PTB) patients to assess if these cellular biomarkers differed between artisanal min...

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Autores principales:	Patrick D. M. C. Katoto, Tony Kayembe-Kitenge, Krystal J. Godri Pollitt, Dries S. Martens, Manosij Ghosh, Jean B. Nachega, Benoit Nemery, Tim S. Nawrot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a865ea49414b4b9981a564775a45a3eb
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spelling	oai:doaj.org-article:a865ea49414b4b9981a564775a45a3eb2021-12-02T14:03:46ZTelomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community10.1038/s41598-021-83281-22045-2322https://doaj.org/article/a865ea49414b4b9981a564775a45a3eb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83281-2https://doaj.org/toc/2045-2322Abstract Telomere length (TL) is a marker of ageing and mitochondrial DNA (mtDNA) is an early marker of inflammation caused by oxidative stress. We determined TL and mtDNA content among active pulmonary tuberculosis (PTB) patients to assess if these cellular biomarkers differed between artisanal miners and non-miners, and to assess if they were predictive of treatment outcome. We conducted a prospective cohort study from August 2018 to May 2019 involving newly diagnosed PTB patients at three outpatient TB clinics in a rural Democratic Republic of Congo. We measured relative TL and mtDNA content in peripheral blood leukocytes (at inclusion) via qPCR and assessed their association with PTB treatment outcome. We included 129 patients (85 miners and 44 non-miners) with PTB (median age 40 years; range 5–71 years, 22% HIV-coinfected). For each increase in year and HIV-coinfection, TL shortened by − 0.85% (− 0.19 to − 0.52) (p ≤ 0.0001) and − 14% (− 28.22 to − 1.79) (p = 0.02) respectively. Independent of these covariates, patients with longer TL were more likely to have successful TB treatment [adjusted hazard ratio; 95% CI 1.27 for a doubling of leucocyte telomere length at baseline; 1.05–1.44] than patients with a shorter TL. Blood mtDNA content was not predictive for PTB outcome. For a given chronological age, PTB patients with longer telomeres at time of diagnosis were more likely to have successful PTB treatment outcome.Patrick D. M. C. KatotoTony Kayembe-KitengeKrystal J. Godri PollittDries S. MartensManosij GhoshJean B. NachegaBenoit NemeryTim S. NawrotNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patrick D. M. C. Katoto Tony Kayembe-Kitenge Krystal J. Godri Pollitt Dries S. Martens Manosij Ghosh Jean B. Nachega Benoit Nemery Tim S. Nawrot Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community
description	Abstract Telomere length (TL) is a marker of ageing and mitochondrial DNA (mtDNA) is an early marker of inflammation caused by oxidative stress. We determined TL and mtDNA content among active pulmonary tuberculosis (PTB) patients to assess if these cellular biomarkers differed between artisanal miners and non-miners, and to assess if they were predictive of treatment outcome. We conducted a prospective cohort study from August 2018 to May 2019 involving newly diagnosed PTB patients at three outpatient TB clinics in a rural Democratic Republic of Congo. We measured relative TL and mtDNA content in peripheral blood leukocytes (at inclusion) via qPCR and assessed their association with PTB treatment outcome. We included 129 patients (85 miners and 44 non-miners) with PTB (median age 40 years; range 5–71 years, 22% HIV-coinfected). For each increase in year and HIV-coinfection, TL shortened by − 0.85% (− 0.19 to − 0.52) (p ≤ 0.0001) and − 14% (− 28.22 to − 1.79) (p = 0.02) respectively. Independent of these covariates, patients with longer TL were more likely to have successful TB treatment [adjusted hazard ratio; 95% CI 1.27 for a doubling of leucocyte telomere length at baseline; 1.05–1.44] than patients with a shorter TL. Blood mtDNA content was not predictive for PTB outcome. For a given chronological age, PTB patients with longer telomeres at time of diagnosis were more likely to have successful PTB treatment outcome.
format	article
author	Patrick D. M. C. Katoto Tony Kayembe-Kitenge Krystal J. Godri Pollitt Dries S. Martens Manosij Ghosh Jean B. Nachega Benoit Nemery Tim S. Nawrot
author_facet	Patrick D. M. C. Katoto Tony Kayembe-Kitenge Krystal J. Godri Pollitt Dries S. Martens Manosij Ghosh Jean B. Nachega Benoit Nemery Tim S. Nawrot
author_sort	Patrick D. M. C. Katoto
title	Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community
title_short	Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community
title_full	Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community
title_fullStr	Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community
title_full_unstemmed	Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community
title_sort	telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a865ea49414b4b9981a564775a45a3eb
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Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community

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