A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection and results in decrease...
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Nature Portfolio
2021
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oai:doaj.org-article:a866230b1fdc4b2fb508ecc62a24397c2021-12-02T16:50:31ZA follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells10.1038/s42003-021-02079-02399-3642https://doaj.org/article/a866230b1fdc4b2fb508ecc62a24397c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02079-0https://doaj.org/toc/2399-3642Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection and results in decreased antibody production, suggesting a potential role for these cells in diseases with dysregulated immune responses.Margaret H. O’ConnorRoshell MuirMarita ChakhtouraMichael FangEirini MoysiSusan MoirAlison J. CareyAlyssa TerkCarmen N. NicholsTalibah MetcalfConstantinos PetrovasMark J. CameronVirginie TardifElias K. HaddadNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Margaret H. O’Connor Roshell Muir Marita Chakhtoura Michael Fang Eirini Moysi Susan Moir Alison J. Carey Alyssa Terk Carmen N. Nichols Talibah Metcalf Constantinos Petrovas Mark J. Cameron Virginie Tardif Elias K. Haddad A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells |
| description |
Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection and results in decreased antibody production, suggesting a potential role for these cells in diseases with dysregulated immune responses. |
| format |
article |
| author |
Margaret H. O’Connor Roshell Muir Marita Chakhtoura Michael Fang Eirini Moysi Susan Moir Alison J. Carey Alyssa Terk Carmen N. Nichols Talibah Metcalf Constantinos Petrovas Mark J. Cameron Virginie Tardif Elias K. Haddad |
| author_facet |
Margaret H. O’Connor Roshell Muir Marita Chakhtoura Michael Fang Eirini Moysi Susan Moir Alison J. Carey Alyssa Terk Carmen N. Nichols Talibah Metcalf Constantinos Petrovas Mark J. Cameron Virginie Tardif Elias K. Haddad |
| author_sort |
Margaret H. O’Connor |
| title |
A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells |
| title_short |
A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells |
| title_full |
A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells |
| title_fullStr |
A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells |
| title_full_unstemmed |
A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells |
| title_sort |
follicular regulatory innate lymphoid cell population impairs interactions between germinal center tfh and b cells |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a866230b1fdc4b2fb508ecc62a24397c |
| work_keys_str_mv |
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