Aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution

Philipp Diebolder,1 Miguel Vazquez-Pufleau,2 Nilantha Bandara,1 Cedric Mpoy,1 Ramesh Raliya,2 Elijah Thimsen,2 Pratim Biswas,2 Buck E Rogers1 1Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, USA; 2Department of Energy, Environmental and Chemical Engineering...

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Autores principales:	Diebolder P, Vazquez-Pufleau M, Bandara N, Mpoy C, Raliya R, Thimsen E, Biswas P, Rogers BE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	silicon silica human tumor xenograft PEGylation 64Cu Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a866ab6e3afe4da1ad64f16b98163ac1
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spelling	oai:doaj.org-article:a866ab6e3afe4da1ad64f16b98163ac12021-12-02T04:56:10ZAerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution1178-2013https://doaj.org/article/a866ab6e3afe4da1ad64f16b98163ac12018-11-01T00:00:00Zhttps://www.dovepress.com/aerosol-synthesized-siliceous-nanoparticles-impact-of-morphology-and-f-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Philipp Diebolder,1 Miguel Vazquez-Pufleau,2 Nilantha Bandara,1 Cedric Mpoy,1 Ramesh Raliya,2 Elijah Thimsen,2 Pratim Biswas,2 Buck E Rogers1 1Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, USA; 2Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, MO, USA Introduction: Siliceous nanoparticles (NPs) have been extensively studied in nanomedicine due to their high biocompatibility and immense biomedical potential. Although numerous technologies have been developed, the synthesis of siliceous NPs for biomedical applications mainly relies on a few core technologies predominantly intended to produce spherical-shaped NPs. Methods: In this context, the impact of different morphologies of siliceous NPs on biodistribution in vivo is limited. In the present study, we developed a novel technique based on an aerosol silane reactor to produce sintered silicon NPs of similar size but different surface areas due to distinct spherical subunits. Silica-converted particles were functionalized for radiolabeling with copper-64 (64Cu) to systematically analyze their behavior in the passive targeting of A431 tumor xenografts in mice after intravenous injection.Results: While low nonspecific uptake was observed in most organs, the majority of particles were accumulated in the liver, spleen, and lung. Depending on the morphologies and functionalization, significant differences in the uptake profiles of the particles were observed. In terms of tumor uptake, spherical shapes with lower surface areas showed the highest accumulation and tumor-to-blood ratios of all investigated particles.Conclusion: This study highlights the importance of shape and fuctionalization of siliceous NPs on organ and tumor accumulation as significant factors for biomedical applications. Keywords: silicon, silica, human tumor xenograft, PEGylation, 64CuDiebolder PVazquez-Pufleau MBandara NMpoy CRaliya RThimsen EBiswas PRogers BEDove Medical Pressarticlesiliconsilicahuman tumor xenograftPEGylation64CuMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7375-7393 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	silicon silica human tumor xenograft PEGylation 64Cu Medicine (General) R5-920
spellingShingle	silicon silica human tumor xenograft PEGylation 64Cu Medicine (General) R5-920 Diebolder P Vazquez-Pufleau M Bandara N Mpoy C Raliya R Thimsen E Biswas P Rogers BE Aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution
description	Philipp Diebolder,1 Miguel Vazquez-Pufleau,2 Nilantha Bandara,1 Cedric Mpoy,1 Ramesh Raliya,2 Elijah Thimsen,2 Pratim Biswas,2 Buck E Rogers1 1Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, USA; 2Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, MO, USA Introduction: Siliceous nanoparticles (NPs) have been extensively studied in nanomedicine due to their high biocompatibility and immense biomedical potential. Although numerous technologies have been developed, the synthesis of siliceous NPs for biomedical applications mainly relies on a few core technologies predominantly intended to produce spherical-shaped NPs. Methods: In this context, the impact of different morphologies of siliceous NPs on biodistribution in vivo is limited. In the present study, we developed a novel technique based on an aerosol silane reactor to produce sintered silicon NPs of similar size but different surface areas due to distinct spherical subunits. Silica-converted particles were functionalized for radiolabeling with copper-64 (64Cu) to systematically analyze their behavior in the passive targeting of A431 tumor xenografts in mice after intravenous injection.Results: While low nonspecific uptake was observed in most organs, the majority of particles were accumulated in the liver, spleen, and lung. Depending on the morphologies and functionalization, significant differences in the uptake profiles of the particles were observed. In terms of tumor uptake, spherical shapes with lower surface areas showed the highest accumulation and tumor-to-blood ratios of all investigated particles.Conclusion: This study highlights the importance of shape and fuctionalization of siliceous NPs on organ and tumor accumulation as significant factors for biomedical applications. Keywords: silicon, silica, human tumor xenograft, PEGylation, 64Cu
format	article
author	Diebolder P Vazquez-Pufleau M Bandara N Mpoy C Raliya R Thimsen E Biswas P Rogers BE
author_facet	Diebolder P Vazquez-Pufleau M Bandara N Mpoy C Raliya R Thimsen E Biswas P Rogers BE
author_sort	Diebolder P
title	Aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution
title_short	Aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution
title_full	Aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution
title_fullStr	Aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution
title_full_unstemmed	Aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution
title_sort	aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/a866ab6e3afe4da1ad64f16b98163ac1
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_version_	1718400970581344256

Aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution

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