The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Differentiating neutrophil functional states is difficult. Here the authors show, using single cell RNA-sequencing and trajectory analyses, that mouse neutrophils can be presented as a transcriptome continuum rather than discrete subsets, but are affected by inflammation to express distinct transcri...

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Autores principales:	Ricardo Grieshaber-Bouyer, Felix A. Radtke, Pierre Cunin, Giuseppina Stifano, Anaïs Levescot, Brinda Vijaykumar, Nathan Nelson-Maney, Rachel B. Blaustein, Paul A. Monach, Peter A. Nigrovic, ImmGen Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a869daba818542d3a779eb3e37bafc52
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spelling	oai:doaj.org-article:a869daba818542d3a779eb3e37bafc522021-12-02T14:58:43ZThe neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments10.1038/s41467-021-22973-92041-1723https://doaj.org/article/a869daba818542d3a779eb3e37bafc522021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22973-9https://doaj.org/toc/2041-1723Differentiating neutrophil functional states is difficult. Here the authors show, using single cell RNA-sequencing and trajectory analyses, that mouse neutrophils can be presented as a transcriptome continuum rather than discrete subsets, but are affected by inflammation to express distinct transcriptional states.Ricardo Grieshaber-BouyerFelix A. RadtkePierre CuninGiuseppina StifanoAnaïs LevescotBrinda VijaykumarNathan Nelson-ManeyRachel B. BlausteinPaul A. MonachPeter A. NigrovicImmGen ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ricardo Grieshaber-Bouyer Felix A. Radtke Pierre Cunin Giuseppina Stifano Anaïs Levescot Brinda Vijaykumar Nathan Nelson-Maney Rachel B. Blaustein Paul A. Monach Peter A. Nigrovic ImmGen Consortium The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
description	Differentiating neutrophil functional states is difficult. Here the authors show, using single cell RNA-sequencing and trajectory analyses, that mouse neutrophils can be presented as a transcriptome continuum rather than discrete subsets, but are affected by inflammation to express distinct transcriptional states.
format	article
author	Ricardo Grieshaber-Bouyer Felix A. Radtke Pierre Cunin Giuseppina Stifano Anaïs Levescot Brinda Vijaykumar Nathan Nelson-Maney Rachel B. Blaustein Paul A. Monach Peter A. Nigrovic ImmGen Consortium
author_facet	Ricardo Grieshaber-Bouyer Felix A. Radtke Pierre Cunin Giuseppina Stifano Anaïs Levescot Brinda Vijaykumar Nathan Nelson-Maney Rachel B. Blaustein Paul A. Monach Peter A. Nigrovic ImmGen Consortium
author_sort	Ricardo Grieshaber-Bouyer
title	The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
title_short	The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
title_full	The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
title_fullStr	The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
title_full_unstemmed	The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
title_sort	neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a869daba818542d3a779eb3e37bafc52
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The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

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