TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation

The correct assembly and recycling of the multicomponent spliceosome remains largely elusive. Here, the authors show that a previously uncharacterized protein TSSC4 associates with de novo formed spliceosomal U5 snRNP as well as with a post-splicing U5-PRPF19 particle, and that TSSC4 is important fo...

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Autores principales:	Klára Klimešová, Jitka Vojáčková, Nenad Radivojević, Franck Vandermoere, Edouard Bertrand, Celine Verheggen, David Staněk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a869db22931543fc89eaa02da0de796a
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spelling	oai:doaj.org-article:a869db22931543fc89eaa02da0de796a2021-12-02T17:40:33ZTSSC4 is a component of U5 snRNP that promotes tri-snRNP formation10.1038/s41467-021-23934-y2041-1723https://doaj.org/article/a869db22931543fc89eaa02da0de796a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23934-yhttps://doaj.org/toc/2041-1723The correct assembly and recycling of the multicomponent spliceosome remains largely elusive. Here, the authors show that a previously uncharacterized protein TSSC4 associates with de novo formed spliceosomal U5 snRNP as well as with a post-splicing U5-PRPF19 particle, and that TSSC4 is important for assembly of the splicing competent tri-snRNP.Klára KlimešováJitka VojáčkováNenad RadivojevićFranck VandermoereEdouard BertrandCeline VerheggenDavid StaněkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Klára Klimešová Jitka Vojáčková Nenad Radivojević Franck Vandermoere Edouard Bertrand Celine Verheggen David Staněk TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation
description	The correct assembly and recycling of the multicomponent spliceosome remains largely elusive. Here, the authors show that a previously uncharacterized protein TSSC4 associates with de novo formed spliceosomal U5 snRNP as well as with a post-splicing U5-PRPF19 particle, and that TSSC4 is important for assembly of the splicing competent tri-snRNP.
format	article
author	Klára Klimešová Jitka Vojáčková Nenad Radivojević Franck Vandermoere Edouard Bertrand Celine Verheggen David Staněk
author_facet	Klára Klimešová Jitka Vojáčková Nenad Radivojević Franck Vandermoere Edouard Bertrand Celine Verheggen David Staněk
author_sort	Klára Klimešová
title	TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation
title_short	TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation
title_full	TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation
title_fullStr	TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation
title_full_unstemmed	TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation
title_sort	tssc4 is a component of u5 snrnp that promotes tri-snrnp formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a869db22931543fc89eaa02da0de796a
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TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation

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