Pathogenesis of IgA Vasculitis: An Up-To-Date Review

Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arth...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yan Song, Xiaohan Huang, Guizhen Yu, Jianjun Qiao, Jun Cheng, Jianyong Wu, Jianghua Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	IgA vasculitis IgA pathogenesis kidney skin Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a86af6d5b80c4edc82d94aa00bd00fca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a86af6d5b80c4edc82d94aa00bd00fca
record_format	dspace
spelling	oai:doaj.org-article:a86af6d5b80c4edc82d94aa00bd00fca2021-11-09T05:25:11ZPathogenesis of IgA Vasculitis: An Up-To-Date Review1664-322410.3389/fimmu.2021.771619https://doaj.org/article/a86af6d5b80c4edc82d94aa00bd00fca2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.771619/fullhttps://doaj.org/toc/1664-3224Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arthritis or arthralgia, abdominal pain, and hematuria or proteinuria. Galactose-deficient IgA1 is detected in the tissues of the kidney and skin in patients with IgAV; it forms immune complexes leading to subsequent immune reactions and injuries. This report provides the recent advances in the understanding of environmental factors, genetics, abnormal innate and acquired immunity, and the role of galactose-deficient IgA1 immunocomplexes in the pathogenesis of IgAV.Yan SongYan SongYan SongYan SongYan SongXiaohan HuangXiaohan HuangXiaohan HuangXiaohan HuangXiaohan HuangGuizhen YuGuizhen YuGuizhen YuGuizhen YuGuizhen YuJianjun QiaoJun ChengJun ChengJun ChengJun ChengJun ChengJianyong WuJianyong WuJianyong WuJianyong WuJianyong WuJianghua ChenJianghua ChenJianghua ChenJianghua ChenJianghua ChenFrontiers Media S.A.articleIgA vasculitisIgApathogenesiskidneyskinImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IgA vasculitis IgA pathogenesis kidney skin Immunologic diseases. Allergy RC581-607
spellingShingle	IgA vasculitis IgA pathogenesis kidney skin Immunologic diseases. Allergy RC581-607 Yan Song Yan Song Yan Song Yan Song Yan Song Xiaohan Huang Xiaohan Huang Xiaohan Huang Xiaohan Huang Xiaohan Huang Guizhen Yu Guizhen Yu Guizhen Yu Guizhen Yu Guizhen Yu Jianjun Qiao Jun Cheng Jun Cheng Jun Cheng Jun Cheng Jun Cheng Jianyong Wu Jianyong Wu Jianyong Wu Jianyong Wu Jianyong Wu Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen Pathogenesis of IgA Vasculitis: An Up-To-Date Review
description	Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arthritis or arthralgia, abdominal pain, and hematuria or proteinuria. Galactose-deficient IgA1 is detected in the tissues of the kidney and skin in patients with IgAV; it forms immune complexes leading to subsequent immune reactions and injuries. This report provides the recent advances in the understanding of environmental factors, genetics, abnormal innate and acquired immunity, and the role of galactose-deficient IgA1 immunocomplexes in the pathogenesis of IgAV.
format	article
author	Yan Song Yan Song Yan Song Yan Song Yan Song Xiaohan Huang Xiaohan Huang Xiaohan Huang Xiaohan Huang Xiaohan Huang Guizhen Yu Guizhen Yu Guizhen Yu Guizhen Yu Guizhen Yu Jianjun Qiao Jun Cheng Jun Cheng Jun Cheng Jun Cheng Jun Cheng Jianyong Wu Jianyong Wu Jianyong Wu Jianyong Wu Jianyong Wu Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen
author_facet	Yan Song Yan Song Yan Song Yan Song Yan Song Xiaohan Huang Xiaohan Huang Xiaohan Huang Xiaohan Huang Xiaohan Huang Guizhen Yu Guizhen Yu Guizhen Yu Guizhen Yu Guizhen Yu Jianjun Qiao Jun Cheng Jun Cheng Jun Cheng Jun Cheng Jun Cheng Jianyong Wu Jianyong Wu Jianyong Wu Jianyong Wu Jianyong Wu Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen
author_sort	Yan Song
title	Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_short	Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_full	Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_fullStr	Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_full_unstemmed	Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_sort	pathogenesis of iga vasculitis: an up-to-date review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a86af6d5b80c4edc82d94aa00bd00fca
work_keys_str_mv	AT yansong pathogenesisofigavasculitisanuptodatereview AT yansong pathogenesisofigavasculitisanuptodatereview AT yansong pathogenesisofigavasculitisanuptodatereview AT yansong pathogenesisofigavasculitisanuptodatereview AT yansong pathogenesisofigavasculitisanuptodatereview AT xiaohanhuang pathogenesisofigavasculitisanuptodatereview AT xiaohanhuang pathogenesisofigavasculitisanuptodatereview AT xiaohanhuang pathogenesisofigavasculitisanuptodatereview AT xiaohanhuang pathogenesisofigavasculitisanuptodatereview AT xiaohanhuang pathogenesisofigavasculitisanuptodatereview AT guizhenyu pathogenesisofigavasculitisanuptodatereview AT guizhenyu pathogenesisofigavasculitisanuptodatereview AT guizhenyu pathogenesisofigavasculitisanuptodatereview AT guizhenyu pathogenesisofigavasculitisanuptodatereview AT guizhenyu pathogenesisofigavasculitisanuptodatereview AT jianjunqiao pathogenesisofigavasculitisanuptodatereview AT juncheng pathogenesisofigavasculitisanuptodatereview AT juncheng pathogenesisofigavasculitisanuptodatereview AT juncheng pathogenesisofigavasculitisanuptodatereview AT juncheng pathogenesisofigavasculitisanuptodatereview AT juncheng pathogenesisofigavasculitisanuptodatereview AT jianyongwu pathogenesisofigavasculitisanuptodatereview AT jianyongwu pathogenesisofigavasculitisanuptodatereview AT jianyongwu pathogenesisofigavasculitisanuptodatereview AT jianyongwu pathogenesisofigavasculitisanuptodatereview AT jianyongwu pathogenesisofigavasculitisanuptodatereview AT jianghuachen pathogenesisofigavasculitisanuptodatereview AT jianghuachen pathogenesisofigavasculitisanuptodatereview AT jianghuachen pathogenesisofigavasculitisanuptodatereview AT jianghuachen pathogenesisofigavasculitisanuptodatereview AT jianghuachen pathogenesisofigavasculitisanuptodatereview
_version_	1718441322794188800

Pathogenesis of IgA Vasculitis: An Up-To-Date Review

Ejemplares similares