Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam

Abstract A birth cohort study was conducted in Khan Hoa Province, central Vietnam between 2009 and 2012 to determine the seroprevalence of hepatitis B virus (HBV) in pregnant women and their children, and associated risk factors. We enrolled 1987 pregnant women with their babies at the birth phase,...

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Autores principales:	Masami Miyakawa, Lay-Myint Yoshida, Hien-Anh Thi Nguyen, Kensuke Takahashi, Tho Huu Le, Michio Yasunami, Koya Ariyoshi, Duc-Anh Dang, Hiroyuki Moriuchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8705c9d673345d594324a91dfe9fe1a
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spelling	oai:doaj.org-article:a8705c9d673345d594324a91dfe9fe1a2021-12-02T13:44:15ZHepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam10.1038/s41598-021-87860-12045-2322https://doaj.org/article/a8705c9d673345d594324a91dfe9fe1a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87860-1https://doaj.org/toc/2045-2322Abstract A birth cohort study was conducted in Khan Hoa Province, central Vietnam between 2009 and 2012 to determine the seroprevalence of hepatitis B virus (HBV) in pregnant women and their children, and associated risk factors. We enrolled 1987 pregnant women with their babies at the birth phase, and 12.6% (95% confidence interval [CI]: 11.1–14.0) of mothers were hepatitis B surface antigen (HBsAg)+. At 2-year follow-up phase, 1339 (67.4%) children were enrolled of whom 76.6% completed hepatitis B vaccines (HepB) and 1.9% (95% CI: 1.2–2.7) were HBsAg+. When mothers were hepatitis B e antigen (HBeAg)+, 28.3% of children have got infected even with complete HepB. HBV infection in mothers, hepatitis B surface antibody (anti-HBs antibody) below the seroprotective level in children, and mothers with pre-pregnancy low body mass index were associated with HBV infection in children. Meanwhile, HBV infection in children, older maternal age, no or incomplete doses of HepB, and boys were associated with anti-HBs antibody below the seroprotective level in children. Our birth cohort study determined a low rate of congenital HBV infection and associated risk factors in Vietnam, however further studies are needed to advance prevention including anti-viral therapy in pregnant women at high risk.Masami MiyakawaLay-Myint YoshidaHien-Anh Thi NguyenKensuke TakahashiTho Huu LeMichio YasunamiKoya AriyoshiDuc-Anh DangHiroyuki MoriuchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masami Miyakawa Lay-Myint Yoshida Hien-Anh Thi Nguyen Kensuke Takahashi Tho Huu Le Michio Yasunami Koya Ariyoshi Duc-Anh Dang Hiroyuki Moriuchi Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam
description	Abstract A birth cohort study was conducted in Khan Hoa Province, central Vietnam between 2009 and 2012 to determine the seroprevalence of hepatitis B virus (HBV) in pregnant women and their children, and associated risk factors. We enrolled 1987 pregnant women with their babies at the birth phase, and 12.6% (95% confidence interval [CI]: 11.1–14.0) of mothers were hepatitis B surface antigen (HBsAg)+. At 2-year follow-up phase, 1339 (67.4%) children were enrolled of whom 76.6% completed hepatitis B vaccines (HepB) and 1.9% (95% CI: 1.2–2.7) were HBsAg+. When mothers were hepatitis B e antigen (HBeAg)+, 28.3% of children have got infected even with complete HepB. HBV infection in mothers, hepatitis B surface antibody (anti-HBs antibody) below the seroprotective level in children, and mothers with pre-pregnancy low body mass index were associated with HBV infection in children. Meanwhile, HBV infection in children, older maternal age, no or incomplete doses of HepB, and boys were associated with anti-HBs antibody below the seroprotective level in children. Our birth cohort study determined a low rate of congenital HBV infection and associated risk factors in Vietnam, however further studies are needed to advance prevention including anti-viral therapy in pregnant women at high risk.
format	article
author	Masami Miyakawa Lay-Myint Yoshida Hien-Anh Thi Nguyen Kensuke Takahashi Tho Huu Le Michio Yasunami Koya Ariyoshi Duc-Anh Dang Hiroyuki Moriuchi
author_facet	Masami Miyakawa Lay-Myint Yoshida Hien-Anh Thi Nguyen Kensuke Takahashi Tho Huu Le Michio Yasunami Koya Ariyoshi Duc-Anh Dang Hiroyuki Moriuchi
author_sort	Masami Miyakawa
title	Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam
title_short	Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam
title_full	Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam
title_fullStr	Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam
title_full_unstemmed	Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam
title_sort	hepatitis b virus infection among pregnant mothers and children after the introduction of the universal vaccination program in central vietnam
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8705c9d673345d594324a91dfe9fe1a
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Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam

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