Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study

Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study

Abstract The rising incidence of bone pathologies such as osteoporosis and osteoarthritis is negatively affecting the functional status of millions of patients worldwide. The genetic component of these multifactorial pathologies is far from being fully understood, but in recent years several epigene...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Clara Pertusa, Juan J. Tarín, Antonio Cano, Miguel Ángel García-Pérez, Damián Mifsut
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a871b5d6f0cf4c43af624f9ac33d7776
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a871b5d6f0cf4c43af624f9ac33d7776
record_format dspace
spelling oai:doaj.org-article:a871b5d6f0cf4c43af624f9ac33d77762021-12-02T17:37:28ZSerum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study10.1038/s41598-021-98789-w2045-2322https://doaj.org/article/a871b5d6f0cf4c43af624f9ac33d77762021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98789-whttps://doaj.org/toc/2045-2322Abstract The rising incidence of bone pathologies such as osteoporosis and osteoarthritis is negatively affecting the functional status of millions of patients worldwide. The genetic component of these multifactorial pathologies is far from being fully understood, but in recent years several epigenetic mechanisms involved in the pathophysiology of these bone diseases have been identified. The aim of the present study was to compare the serum expression of four miRNAs in women with hip fragility fracture (OF group), osteoarthritis requiring hip replacement (OA group) and control women (Ctrl group). Serum expression of miR-497-5p, miR-155-5p, miR-423-5p and miR-365-3p was determined in a sample of 23 OA women, 25 OF women and 52 Ctrl women. Data shown that women with bone pathologies have higher expression of miR-497 and miR-423 and lower expression of miR-155 and miR-365 than control subjects. Most importantly, miR-497 was identified as an excellent discriminator between OA group and control group (AUC: 0.89, p < 0.000) and acceptable in distinguishing from the OF group (AUC: 0.76, p = 0.002). Our data suggest that circulating miR-497 may represent a significant biomarker of OA, a promising finding that could contribute towards future early-stage diagnosis of this disease. Further studies are required to establish the role of miR-155, miR-423 and miR-365 in bone pathologies.Clara PertusaJuan J. TarínAntonio CanoMiguel Ángel García-PérezDamián MifsutNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Clara Pertusa
Juan J. Tarín
Antonio Cano
Miguel Ángel García-Pérez
Damián Mifsut
Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study
description Abstract The rising incidence of bone pathologies such as osteoporosis and osteoarthritis is negatively affecting the functional status of millions of patients worldwide. The genetic component of these multifactorial pathologies is far from being fully understood, but in recent years several epigenetic mechanisms involved in the pathophysiology of these bone diseases have been identified. The aim of the present study was to compare the serum expression of four miRNAs in women with hip fragility fracture (OF group), osteoarthritis requiring hip replacement (OA group) and control women (Ctrl group). Serum expression of miR-497-5p, miR-155-5p, miR-423-5p and miR-365-3p was determined in a sample of 23 OA women, 25 OF women and 52 Ctrl women. Data shown that women with bone pathologies have higher expression of miR-497 and miR-423 and lower expression of miR-155 and miR-365 than control subjects. Most importantly, miR-497 was identified as an excellent discriminator between OA group and control group (AUC: 0.89, p < 0.000) and acceptable in distinguishing from the OF group (AUC: 0.76, p = 0.002). Our data suggest that circulating miR-497 may represent a significant biomarker of OA, a promising finding that could contribute towards future early-stage diagnosis of this disease. Further studies are required to establish the role of miR-155, miR-423 and miR-365 in bone pathologies.
format article
author Clara Pertusa
Juan J. Tarín
Antonio Cano
Miguel Ángel García-Pérez
Damián Mifsut
author_facet Clara Pertusa
Juan J. Tarín
Antonio Cano
Miguel Ángel García-Pérez
Damián Mifsut
author_sort Clara Pertusa
title Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study
title_short Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study
title_full Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study
title_fullStr Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study
title_full_unstemmed Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study
title_sort serum micrornas in osteoporotic fracture and osteoarthritis: a genetic and functional study
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a871b5d6f0cf4c43af624f9ac33d7776
work_keys_str_mv AT clarapertusa serummicrornasinosteoporoticfractureandosteoarthritisageneticandfunctionalstudy
AT juanjtarin serummicrornasinosteoporoticfractureandosteoarthritisageneticandfunctionalstudy
AT antoniocano serummicrornasinosteoporoticfractureandosteoarthritisageneticandfunctionalstudy
AT miguelangelgarciaperez serummicrornasinosteoporoticfractureandosteoarthritisageneticandfunctionalstudy
AT damianmifsut serummicrornasinosteoporoticfractureandosteoarthritisageneticandfunctionalstudy
_version_ 1718379899928969216

Ejemplares similares